DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and qsox2

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_009300239.1	Gene:	qsox2 / 559603	ZFINID:	ZDB-GENE-110203-4	Length:	656	Species:	Danio rerio

Alignment Length:	576	Identity:	182/576 - (31%)
Similarity:	287/576 - (49%)	Gaps:	84/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YCLLLISPADVLGRLNARKSANEASLYSDTDNVIMLDIESLR-PALNLKNSKLVQFLNSFCGDCH 73
            :||.:   :.::|.|..|  |..|.||::.|.|::|..:||: ..||..::.||||.:|:||.|.
Zfish     5 FCLKI---SIIVGLLFGR--AQPARLYTEEDPVVILSSDSLKQTVLNSSSAWLVQFYSSWCGHCI 64

  Fly    74 RFAPVFKTLSRDLYKWRRILRIYAVDCAQERNAQLCREFNIRQTPSLRFFGPDMRKNDDVLGAVI 138
            :::|.:|.|:.|:..|.:.:||..||||.|:|..:|:||.|...|:.|:|......||  .|...
Zfish    65 QYSPTWKALAGDVKDWAQAIRIGVVDCAHEKNFDICKEFGIHFYPTFRYFKAHDTTND--FGKTY 127

  Fly   139 PGQDPEFISSTLAELV-------SQNDYGPGQPNFRPLKATDYEIFQDQDGETPIQFVALVLQPK 196
            .|.|.|.  .|:.:|:       ::.|:..|.|...|.::.|.....   |:....:.|::::..
Zfish   128 QGADREL--QTVRQLMVNFIQNHTRQDWPVGCPPLHPARSEDVLSLM---GKKTEHYTAVIVEDG 187

  Fly   197 NSKIGRDTLLELLPFKELSVR--IIEDSQIFNEFGLGPDDQKLAIVDRNGTAQYLTPSSDSSEAY 259
            ||.|||:.:|:|:|::.|.|:  :..|..:.::.|:. ......:...|||...|.........:
Zfish   188 NSYIGREVILDLMPYEGLVVKRALSSDQLLMDKLGIS-SVPSAYLFQPNGTHTVLNVQKKLRFFF 251

  Fly   260 ASTIGDFLKNRNIQPDPPLPIAVAPNFTEFLDHQNQAILTKVLTPP------------------L 306
            :|    |||             :.|..     |:.|:  |..|..|                  .
Zfish   252 SS----FLK-------------LLPGV-----HRKQS--TSSLQRPQPGINGQGAQVEWKEFKKS 292

  Fly   307 QVYRADLEQAIDKLLHIELRKWVLLEGNSLNALKNIIKIFRYLNPLNKD-GKLLLTDLDNSLSSK 370
            :||.||||..:..||.:||.....|||..|...|:.:.:...|.|.::. .|||.|.|:..:|
Zfish   293 KVYMADLESGLHYLLRVELATHKTLEGEELKTFKDFVTVVAKLFPGHQSVVKLLETLLEWLVS-- 355

  Fly   371 QSIKGADFGDLVDSLENGRRV-----FKARRYVGCIGSRPLLRSFTCSMWTLFHHLTVEAAKPPN 430
            ..::...:..::|.:.|..|:     .:..::|||.||...||.:.||:|||||.|||:||..|:
Zfish   356 LPLEKIPYDAILDLVNNKMRISGLYLSEQVQWVGCQGSSVALRGYPCSLWTLFHVLTVQAANRPD 420

  Fly   431 Y-----FEAG--SILKTFHGFAKYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVN 488
            .     ||..  ::|:|...:...||||.:|.:||::|| :.:|..|||.||.:||||..||:||
Zfish   421 ALANTGFEDDPLAVLQTMRRYIGTFFGCQECGKHFEEMA-QESLNQVKTVDEAVLWLWRKHNQVN 484

  Fly   489 ARIAGDSTEDPKFPKIQFPSAENCPTCRSNDS---EWRTDEVLKYLKQLYDINNVS 541
            ||::|..:|||.|||.|:|:.:.||||.....   .|....||.:|||.|..:|:|
Zfish   485 ARLSGSMSEDPMFPKTQWPTPDLCPTCHEEQEGLHVWNEQMVLAFLKQHYSASNIS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	42/112 (38%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	47/97 (48%)
qsox2	XP_009300239.1	PDI_a_QSOX	30..141	CDD:239290	42/114 (37%)
qsox2	XP_009300239.1	Evr1_Alr	403..499	CDD:282612	46/96 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579247
Domainoid	1	1.000	115	1.000	Domainoid score	I5973
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65608
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2961
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm6583
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800