DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox3 and Qsox1

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001103368.1	Gene:	Qsox1 / 84491	RGDID:	68957	Length:	750	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	159/599 - (26%)
Similarity:	276/599 - (46%)	Gaps:	95/599 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HFWVPYLTCIILILIVQEGHSKQRCLDEEPP---------------LYSKEDNIHVVVGASLKKI 53
            |...|.|..::|:|               ||               |||..|.:.::...:::..
  Rat     7 HSGPPSLLLLLLLL---------------PPLLLSVPGAYAARLSVLYSSSDPLTLLDADTVRPA 56

  Fly    54 LAEPAMGKLVQFLNSYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLT 118
            :...:....|:|..|:||:|..||.|::::|.|::.|...|.:..:|||...|..:||:|.|...
  Rat    57 VLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCADETNSAVCREFNIAGF 121

  Fly   119 PTIRYYPSKFQRIRHGIGTDIETTIPSEIAD------QLIESLSENDYSESKGVKPIFDPIEPGN 177
            ||:|::.: |.  ::|.|    |.:|:..|:      :||::|.    |......|...|:||.
  Rat   122 PTVRFFKA-FS--KNGTG----TALPAAGANVQTLRMRLIDALE----SHRDTWPPACPPLEPA- 174

  Fly   178 KLNDIYEQFD-NKVTYILLVHPVD---MGIETILNMLPYPDVGVRIIKDAE-----MFAQFGLKP 233
            ||.||.|.|. :|..|:.|:...:   :|.|..|::..:..|.||.:.::|     .||......
  Rat   175 KLKDINEFFTRSKAEYLALIFEREDSYLGREVTLDLSQFHAVAVRRVLNSESDVVSKFAVTDFPS 239

  Fly   234 CKQMVALLNRSGKAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAEPEYILSEGYDAFIVD 298
            |    .||.|:|....:....:|...|...:.||..........|..|..|:.|      |..|.
  Rat   240 C----YLLLRNGSVSRVPVLVESRPFYTSYLRGLPGLTREAPPTTAAPVTPDKI------APTVW 294

  Fly   299 YVLNSTKVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHIIRLFRRFNVLNRDGRRMLNSLV 363
            ...:.:|: :.||||.|::..|.||:.|.:.:.|.:..||:..:.:..::    ..|:.::.:.:
  Rat   295 KFADRSKI-YMADLESALHYILRVEVGKFSVLEGQRLVALKKFVAVLAKY----FPGQPLVQNFL 354

  Fly   364 NHL------FEVTEITGEEFRDVVDDLQTRLDPIFAEQ-QYVGCLGSTPHTRRFSCSLWTLFHYF 421
            :.:      .:..:|....|:..:|  ..:.:.:.||: .::||.||.||.|.|.||||.|||:.
  Rat   355 HSINDWLQKQQKKKIPYSYFKAALD--SRKENAVLAEKVNWIGCQGSEPHFRGFPCSLWVLFHFL 417

  Fly   422 TVLAAQMKVYPPSSVTIG------LYGLAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLW 480
            ||.|.:.....|.....|      :....:.|:.|:|.:.:|.::| ..::.:|::....:||||
  Rat   418 TVQAHRYSEAHPQEPADGQEVLQAMRSYVQSFFGCRDCANHFEQMA-AASMHQVKSPSNAVLWLW 481

  Fly   481 EAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCYTH-SGE---FDRDEVLKYLKRVYNLSYLSG 541
            .:||.||.:|:|..|.||:|||||:|.|:.|..|:.. :|:   :|....|.:||..::.:.:..
  Rat   482 TSHNRVNARLSGALSEDPQFPKVQWPPRELCSACHNEVNGQVPLWDLGATLNFLKAHFSPANIVR 546

  Fly   542 DAE---PHSRRSNE 552
            |..   |.|||..:
  Rat   547 DPPAPGPASRRGTQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	32/118 (27%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	32/95 (34%)
Qsox1	NP_001103368.1	PDI_a_QSOX	43..155	CDD:239290	32/118 (27%)
		Evr1_Alr	409..504	CDD:282612	32/95 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..567		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..632
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339520
Domainoid	1	1.000	51	1.000	Domainoid score	I11276
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8977
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.720