DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox3 and Qsox2

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001102904.1	Gene:	Qsox2 / 681023	RGDID:	1584720	Length:	708	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	159/602 - (26%)
Similarity:	266/602 - (44%)	Gaps:	104/602 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IILILIV------QEGHSKQRCLDEEPPLYS-KEDNIHVVVGASLKKILAEPAMGKLVQFLNSYC 70
            ::|:|.|      |||...:        ||. .||.:.::...|::......:...||||.:|:|
  Rat    45 LLLLLAVVAAVGPQEGGGAR--------LYRVGEDAVWLLDSGSVRSATGNSSAAWLVQFHSSWC 101

  Fly    71 GNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLTPTIRY---YPSKFQRIR 132
            |:|..:|.|:|.:|.|::.|...:|:.|:|||..:|..:||.:.|...||.||   :..:|....
  Rat   102 GHCIGYAPTWRALAADVRDWAAAIRVAALDCAEEKNQDVCRTYDIHFYPTFRYFRAFTKEFTTGE 166

  Fly   133 HGIGTDIETTIPSEIADQLIESLSENDYSESKGVKPIFDPIEPGNKLNDIYEQ--------FDNK 189
            :..|.|.|.   ..:...:|:.|..:.........|..|||:..:.|:.:...        |::.
  Rat   167 NFKGPDREL---RTVRQTMIDFLQNHTEGSRPPACPPLDPIQSSDILSFMDSHSGQYHAVVFESN 228

  Fly   190 VTYILLVHPVDMGIETILNMLPYPDVGV--RIIKDAEMFAQFGLK--PCKQMVALLNRSGKAQLI 250
            .:|:        |.|.||:::||.::.|  .:..|.......|:.  |...::......|...:.
  Rat   229 GSYV--------GREVILDLIPYDNIMVSRALDTDKAFLGTLGISSVPSCYLIYPNGSHGLVNVA 285

  Fly   251 KPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAE--PEYILSEGYDAFIVDYVLNSTKVLFQADLE 313
            ||.....|:|::|:..:..::  .|:|..|..|  .|.::.:.:|          ...|:.||||
  Rat   286 KPLRSFFSSYLKSLPDVRKKS--LSLPEKPNKEENSEVVIWKEFD----------RAKLYTADLE 338

  Fly   314 QAIYQFLHVEIPKTAFISGFKFKALRH----IIRLFRRFNVLNRDGRRMLNSLVNHLFE------ 368
            ..::..|.||:.....::|.:.|..:.    |.:||        .||..:..|:..|.|
  Rat   339 SGLHYLLRVELAAHRSLAGAQLKTFKDFVTVIAKLF--------PGRPPVKKLLETLHEWLANLP 395

  Fly   369 VTEITGEEFRDVVDDLQTRLDPIFAEQQ--YVGCLGSTPHTRRFSCSLWTLFHYFTVLAAQMKVY 431
            :.:|......|:|:: :.::..:|....  :|||.||....|.:.||||.|||..||   |...:
  Rat   396 LDKIPYNAILDLVNN-KMQISGLFLTSHITWVGCQGSRLELRGYPCSLWKLFHTLTV---QASTH 456

  Fly   432 PPSSVTIGLYG-----------LAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLWEAHNE 485
            |.:.|..|..|           ..:.|:.||:...:|.::||. ::..|:|.|:.:||||..||.
  Rat   457 PEALVGTGFEGDPQAVLQTMRRYIRTFFGCKECGEHFEEMAKE-SMDSVKTADQAVLWLWRKHNM 520

  Fly   486 VNEKLAGDASGDPRFPKVQFPERKHCPDCYTH---SGEFDRDEVLKYLKRVYNLSYL-------- 539
            ||.:|||..|.||:||||.:|....||.|:..   ...:|.::||.:||:.|:...|
  Rat   521 VNSRLAGHLSEDPKFPKVPWPTPDLCPVCHEEIKGLDSWDEEQVLVFLKQHYSRDNLVDTYSVDQ 585

  Fly   540 --SGDAEPHSRRSNECK 554
              .|:.|...||..|.|
  Rat   586 GSPGEWEGMGRRQEEGK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	33/115 (29%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	38/100 (38%)
Qsox2	NP_001102904.1	PDI_a_QSOX	71..184	CDD:239290	33/115 (29%)
Qsox2	NP_001102904.1	Evr1_Alr	441..538	CDD:282612	38/100 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339516
Domainoid	1	1.000	51	1.000	Domainoid score	I11276
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65608
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8977
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.720