DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox3 and QSOX1

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_002817.2	Gene:	QSOX1 / 5768	HGNCID:	9756	Length:	747	Species:	Homo sapiens

Alignment Length:	563	Identity:	158/563 - (28%)
Similarity:	269/563 - (47%)	Gaps:	69/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PYLTCIILILIVQEGHSKQRCLDEEPPLYSKEDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGN 72
            |.|..::|.|:...|.:..    ....|||..|.:.::...:::..:........|:|..|:||:
Human    12 PSLLLLLLWLLAVPGANAA----PRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGH 72

  Fly    73 CRRFAHTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLTPTIRYYPSKFQRIRHG--- 134
            |..||.|::.:|.|::.|...|.:.|:|||...|..:||||.|...||:|::.: |.:...|
Human    73 CIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKA-FTKNGSGAVF 136

  Fly   135 --IGTDIETTIPSEIADQLIESLSENDYSESKGVKPIFDPIEPGNKLNDIYEQF-DNKVTYILLV 196
              .|.|::|     :.::||::|.    |......|...|:||. ||.:|...| .|...|:.|:
Human   137 PVAGADVQT-----LRERLIDALE----SHHDTWPPACPPLEPA-KLEEIDGFFARNNEEYLALI 191

  Fly   197 HPVD---MGIETILNMLPYPDVGVRII--KDAEMFAQFGLKPCKQMVALLNRSGKAQLIKPAGKS 256
            ....   :|.|..|::..:..|.||.:  .:|.:..:||:....... ||.|:|....:....:|
Human   192 FEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCY-LLFRNGSVSRVPVLMES 255

  Fly   257 SS---AYVESVAGLLHQNGHTSMPTLPPAEPEYILSEGYDAFIVDYVLNSTKVLFQADLEQAIYQ 318
            .|   ||::.::||..:...|   |:.|.....|      |..|..:.:.:|: :.||||.|::.
Human   256 RSFYTAYLQRLSGLTREAAQT---TVAPTTANKI------APTVWKLADRSKI-YMADLESALHY 310

  Fly   319 FLHVEIPKTAFISGFKFKALRHIIRLFRRFNVLNRDGRRMLNSLVNHLFEVTE---------ITG 374
            .|.:|:.:...:.|.:..||:..:.:..::    ..||.::.   |.|..|.|         |..
Human   311 ILRIEVGRFPVLEGQRLVALKKFVAVLAKY----FPGRPLVQ---NFLHSVNEWLKRQKRNKIPY 368

  Fly   375 EEFRDVVDDLQTRLDPIFAEQ-QYVGCLGSTPHTRRFSCSLWTLFHYFTVLAAQMKV------YP 432
            ..|:..:||  .:...:.|:: .::||.||.||.|.|.||||.|||:.||.||:..|      ..
Human   369 SFFKTALDD--RKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAK 431

  Fly   433 PSSVTIGLYGLAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGD 497
            ...|...:.|...:|:.|:|.:.:|.::| ..::.:|.:.:..:||||.:||.||.:|||..|.|
Human   432 AKEVLPAIRGYVHYFFGCRDCASHFEQMA-AASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSED 495

  Fly   498 PRFPKVQFPERKHCPDCYTHSGE---FDRDEVLKYLKRVYNLS 537
            |:|||||:|.|:.|..|:....:   :|.:..|.:||..::.|
Human   496 PQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPS 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	33/117 (28%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	35/95 (37%)
QSOX1	NP_002817.2	PDI_a_QSOX	40..152	CDD:239290	33/117 (28%)
		Evr1_Alr	406..501	CDD:282612	35/95 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145811
Domainoid	1	1.000	45	1.000	Domainoid score	I12204
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4784
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8504
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.670