DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox3 and QSOX2

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_859052.3	Gene:	QSOX2 / 169714	HGNCID:	30249	Length:	698	Species:	Homo sapiens

Alignment Length:	533	Identity:	152/533 - (28%)
Similarity:	254/533 - (47%)	Gaps:	67/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCAR 103
            ||.:.|:...|::...|..:...||||.:|:||:|..:|.|:|.:|.|::.|...:|:.|:||..
Human    60 EDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCME 124

  Fly   104 LENVKLCRDFRITLTPTIRYYPS---KFQRIRHGIGTDIETTIPSEIADQLIESLSENDYSESKG 165
            .:|..:|.|:.|...||.||:.:   :|....:..|.|.|.   ..:...:|:.|..:.......
Human   125 EKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDREL---RTVRQTMIDFLQNHTEGSRPP 186

  Fly   166 VKPIFDPIEPGNKLNDIYEQFDNKVT-YILLVHPVD---MGIETILNMLPYPDVGVRIIKDAE-- 224
            ..|..|||:|    :|:....||:.: |:.:|...:   :|.|.||:::||..:.|....|.:
Human   187 ACPRLDPIQP----SDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKA 247

  Fly   225 MFAQFGLK--PCKQMVALLNRSGKAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAEPEYI 287
            ...:.|:.  |...::......|...::||.....|:|::|:..:..:    |:|.  |.:|.
Human   248 FLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKK----SLPL--PEKPH-- 304

  Fly   288 LSEGYDAFIVDYVLNSTKVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHII----RLFRRF 348
             .|.....:|....:.:| |:..|||..::..|.||:.....::|.:.|.|:..:    :||
Human   305 -KEENSEIVVWREFDKSK-LYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLF--- 364

  Fly   349 NVLNRDGRRMLNSLVNHLFE------VTEITGEEFRDVVDDLQTRLDPIFAEQ--QYVGCLGSTP 405
                 .||..:..|:..|.|      :..|......|:|:: :.|:..||...  ::|||.||..
Human   365 -----PGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNN-KMRISGIFLTNHIKWVGCQGSRS 423

  Fly   406 HTRRFSCSLWTLFHYFTVLAAQMKVYPPSSVTIG--------LYGLAKF---FYDCKDGSMYFVK 459
            ..|.:.||||.|||..||.|:   .:|.:.|..|        |..:.::   |:.||:...:|.:
Human   424 ELRGYPCSLWKLFHTLTVEAS---THPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEE 485

  Fly   460 LAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCYTH---SGEF 521
            :||. ::..|:|.|:.|||||:.||.||.:|||..|.||||||:|:|....||.|:..   ...:
Human   486 MAKE-SMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASW 549

  Fly   522 DRDEVLKYLKRVY 534
            |...||.:||:.|
Human   550 DEGHVLTFLKQHY 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	34/115 (30%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	40/100 (40%)
QSOX2	NP_859052.3	PDI_a_QSOX	61..174	CDD:239290	34/115 (30%)
		Evr1_Alr	431..527	CDD:282612	39/99 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145807
Domainoid	1	1.000	107	1.000	Domainoid score	I6520
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65608
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8504
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.720