DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox3 and Qsox1

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001020116.1	Gene:	Qsox1 / 104009	MGIID:	1330818	Length:	748	Species:	Mus musculus

Alignment Length:	551	Identity:	156/551 - (28%)
Similarity:	264/551 - (47%)	Gaps:	68/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LYSKEDNIHVVVGASLKKILAEPAMGKLVQFLNSYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAV 99
            |||..|.:.::...|::..:...:....|:|..|:||:|..||.|::::|.|::.|...|.:..:
Mouse    38 LYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVL 102

  Fly   100 DCARLENVKLCRDFRITLTPTIRYYPSKFQRI-RHGIGTDIETTIPSEIAD------QLIESLSE 157
            |||...|..:||:|.|...||:|:    ||.. ::|.|    .|:|...|:      :||::|.
Mouse   103 DCAEETNSAVCREFNIAGFPTVRF----FQAFTKNGSG----ATLPGAGANVQTLRMRLIDALE- 158

  Fly   158 NDYSESKGVKPIFDPIEPGNKLNDIYEQFD-NKVTYILLVHPVD---MGIETILNMLPYPDVGVR 218
               |......|...|:||. |||||...|. ||..|:.||...:   :|.|..|::..|..|.||
Mouse   159 ---SHRDTWPPACPPLEPA-KLNDIDGFFTRNKADYLALVFEREDSYLGREVTLDLSQYHAVAVR 219

  Fly   219 II--KDAEMFAQFGLKPCKQMVALLNRSGKAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTL-- 279
            .:  .::::..:||:........|| |:|....:....:|.|.|...:.||         |.|
Mouse   220 RVLNTESDLVNKFGVTDFPSCYLLL-RNGSVSRVPVLVESRSFYTSYLRGL---------PGLTR 274

  Fly   280 --PPAEPEYILSEGYDAFIVDYVLNSTKVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHII 342
              ||.....:.::.....:..:...|.  ::.||||.|::..|.||:.|.:.:.|.:..||:..:
Mouse   275 DAPPTTATPVTADKIAPTVWKFADRSK--IYMADLESALHYILRVEVGKFSVLEGQRLVALKKFV 337

  Fly   343 RLFRRFNVLNRDGRRMLNSLVNHLFEVTE------ITGEEFRDVVDDLQTRLDPIFAEQ-QYVGC 400
            .:..::    ..|:.::.:.::.:.:..:      |....|:..:|  ..:.|.:..|: .:|||
Mouse   338 AVLAKY----FPGQPLVQNFLHSINDWLQKQQKKRIPYSFFKAALD--SRKEDAVLTEKVNWVGC 396

  Fly   401 LGSTPHTRRFSCSLWTLFHYFTVLAAQMKVYPPSSVTIG------LYGLAKFFYDCKDGSMYFVK 459
            .||.||.|.|.||||.|||:.||.|.:.....|.....|      :....:||:.|:|.:.:|.:
Mouse   397 QGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEPADGQEVLQAMRSYVQFFFGCRDCADHFEQ 461

  Fly   460 LAKRMNIAKVRTHDEEILWLWEAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCYTH-SGE--- 520
            :| ..::.:||:....|||||.:||.||.:|:|..|.||.|||||:|.|:.|..|:.. :|:
Mouse   462 MA-AASMHQVRSPSNAILWLWTSHNRVNARLSGALSEDPHFPKVQWPPRELCSACHNELNGQVPL 525

  Fly   521 FDRDEVLKYLKRVYNLS--YLSGDAEPHSRR 549
            :|....|.:||..::.:  .:...|..|:.|
Mouse   526 WDLGATLNFLKAHFSPANIVIDSSASRHTGR 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	34/119 (29%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	35/95 (37%)
Qsox1	NP_001020116.1	PDI_a_QSOX	43..155	CDD:239290	34/119 (29%)
		Evr1_Alr	409..501	CDD:282612	33/92 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835883
Domainoid	1	1.000	52	1.000	Domainoid score	I11376
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4784
OMA	1	1.010	-	-		QHG48718
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8738
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.660