DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Qsox3 and qsox1

DIOPT Version :9

Sequence 1:	NP_650997.1	Gene:	Qsox3 / 42582	FlyBaseID:	FBgn0038918	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001121836.1	Gene:	qsox1 / 100004382	ZFINID:	ZDB-GENE-030131-7019	Length:	778	Species:	Danio rerio

Alignment Length:	586	Identity:	157/586 - (26%)
Similarity:	273/586 - (46%)	Gaps:	102/586 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WHFWVPYLTCIILILIVQEGHSKQRCLDEEPPLYSKEDNIHVVVGASLKKILAEPAMGKLVQFLN 67
            :.|...::||:.|..::        |   |..||:..|.:.|:...::...|.......||:|..
Zfish    22 YSFLCAFITCVSLCPVL--------C---EAGLYTASDQVIVLTPENVDSTLFNNTAALLVEFYA 75

  Fly    68 SYCGNCRRFAHTFRKMAVDLQKWNRVLRIYAVDCARLENVKLCRDFRITLTPTIRYY------PS 126
            ::||:|..|:..::.:|.|:::|...:.:.|:|||...|.|:|.:|.||..|:|:::      .|
Zfish    76 TWCGHCIAFSPVWKSLARDIKEWKPAVDLAAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGS 140

  Fly   127 KFQRIRHGIGTDIETTIPSEIADQLIESLSENDYSESKGVKPIFDPIE-----------PGNKLN 180
            :...:| |...|:.     .:...:||:|.    ..::...|...|:|           |.|.:.
Zfish   141 RGLEVR-GFSRDVR-----GLRQYIIENLE----LHTEAWPPACPPLETASEAEVHHFFPANNVK 195

  Fly   181 DIYEQFDNKVTYILLVHPVDMGIETILNMLPYPDVGVRIIKDAE--MFAQFGLKPCKQMVALLNR 243
            .:...|:||.:|:        |.|..|::|.|.::.||.:.|.|  :.::||:....... |.:.
Zfish   196 YLALVFENKKSYV--------GREVTLDLLQYENIAVRRVLDTETNLVSRFGVTEFPSCY-LYDS 251

  Fly   244 SG---KAQLIKPAGKSSSAYVESVAGLLHQNGHTSMPTLPPAEPEYILSEGYDAFIVDYVLNST- 304
            ||   :.:::|.|....|..::.:.|::....|.:.                   |.:.:.|||
Zfish   252 SGNITRLKVLKEARTFYSYALQRLPGVVRTGKHQTP-------------------ITELIKNSTL 297

  Fly   305 --------KVLFQADLEQAIYQFLHVEIPKTAFISGFKFKALRHIIRLFRRFNVLNR--DGRRML 359
                    ..::.:|||.|::..|.||:.....|||....||:..|      |||.:  .||..:
Zfish   298 QEWRPFNKSRVYMSDLESALHYSLRVELSSHTSISGDDLIALKKYI------NVLAKYFPGRPSV 356

  Fly   360 NSLVNHL------FEVTEITGEEFRDVVDDLQTRLDPIFAE-QQYVGCLGSTPHTRRFSCSLWTL 417
            .|.:..:      .:.|||...:||||:|::....|.:..| .|:|||.||....|.:.|::|||
Zfish   357 KSALQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTSDAVLPEGVQWVGCQGSQARYRGYPCAVWTL 421

  Fly   418 FHYFTVLAAQM--KVYPPSSVTIGLYGLAKFFYDCKDGSMYFVKLAKRMNIAKVRTHDEEILWLW 480
            ||..||.|.:|  .|..|..|.:.:.|....|:.|:..:.:|..:|.. ::.:|.:....::|||
Zfish   422 FHVLTVQAKEMGSTVSEPQEVLLAMRGYVSSFFGCRPCATHFEAMAAE-SMDQVNSLSGAVIWLW 485

  Fly   481 EAHNEVNEKLAGDASGDPRFPKVQFPERKHCPDCY--THSGEFD--RDEVLKYLKRVYNLSYLSG 541
            ..||.||.:||||.|.||.|||:|:|..:.||.|:  |..|:.:  :|||.::|:..::.|.:..
Zfish   486 SRHNRVNNRLAGDLSEDPHFPKIQWPSPELCPSCHGVTIIGDHNWIKDEVPQFLQNYFSSSRILN 550

  Fly   542 D 542
            |
Zfish   551 D 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox3	NP_650997.1	PDI_a_QSOX	40..153	CDD:239290	29/118 (25%)
Qsox3	NP_650997.1	Evr1_Alr	413..503	CDD:282612	34/91 (37%)
qsox1	NP_001121836.1	PDI_a_QSOX	48..161	CDD:239290	29/118 (25%)
qsox1	NP_001121836.1	Evr1_Alr	417..508	CDD:282612	34/91 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579253
Domainoid	1	1.000	45	1.000	Domainoid score	I12168
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm6583
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.720