Protein Alignment CG6678 and HERC2

DIOPT Version :9

• Sequence 1: NP_650996.1
• Gene: CG6678 / 42581
• FlyBaseID: FBgn0038917
• Length: 373
• Species: Drosophila melanogaster
• Sequence 2: NP_004658.3
• Gene: HERC2 / 8924
• HGNCID: 4868
• Length: 4834
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 81/327 - (24%)
• Similarity: 122/327 - (37%)
• Gaps: 127/327 - (38%)

  Fly    44 IGWRYAALAFGRKLCLRGLLDDGPNECVTLEATGNIRALAAADSHCLVLLQSGQLYRVQPKLQAE 108
            |||:|.|...            ||.:|..|...| :..:|.|:...|:|.::|::|     .||
Human   431 IGWKYYANVI------------GPIQCEGLANLG-VTQIACAEKRFLILSRNGRVY-----TQA- 476

  Fly   109 LVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEHIACGSHINVAISSENCVYSIPSCLHQFSERQ 173
                       .||.|        .||.  :::.:|..:.:.:|..|:
Human   477 -----------YNSDT--------LAPQ--LVQGLASRNIVKIAAHSD----------------- 503

  Fly   174 FRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAELRVEETPQLLEAL----AGIKITQIAAG 234
                    || |.:.|.|.|:|::||.|..|:||..:....|.|:::.|.    ||..:..||.|
Human   504 --------GH-HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 559

  Fly   235 GWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLPECACSQSGESNDDCA 299
            ..:||||:|.|:|||||....|:||                               .|.|.|:..
Human   560 STYSAAITAEGELYTWGRGNYGRLG-------------------------------HGSSEDEAI 593

  Fly   300 PLRVF-------------AGSRHTLLIRRCGRLWVSGWCKHGQLGR-------------QLQDLS 338
            |:.|.             :|...||.:...|::|..|...:|:|||             :||||.
Human   594 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLD 658

  Fly   339 YV 340
            .|
Human   659 VV 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	71/293 (24%)
		RCC1_2	176..205	CDD:290274	10/28 (36%)
		RCC1	192..241	CDD:278826	18/52 (35%)
		RCC1_2	228..257	CDD:290274	14/28 (50%)
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	415..461		12/42 (29%)
		RCC1 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	462..512		18/102 (18%)
		RCC1 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	513..568		20/54 (37%)
		RCC1	514..566	CDD:278826	18/51 (35%)
		RCC1 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	569..620		17/81 (21%)
		RCC1	569..620	CDD:278826	17/81 (21%)
		RCC1 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	623..674		12/38 (32%)
		RCC1	623..672	CDD:278826	12/38 (32%)
		RCC1 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		RCC1 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	2958..3009
		RCC1	2960..3007	CDD:278826
		RCC1 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3010..3064
		RCC1	3010..3062	CDD:278826
		RCC1 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3065..3116
		RCC1	3065..3114	CDD:278826
		RCC1	3117..3168	CDD:278826
		RCC1 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3118..3168
		RCC1 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3171..3222
		RCC1	3171..3220	CDD:278826
		RCC1	3223..3272	CDD:278826
		RCC1 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3224..3274
		RCC1 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3275..3326
		RCC1	3275..3324	CDD:278826
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3602..3629
		RCC1 3-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3951..4002
		RCC1 3-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4004..4056
		RCC1_2	4039..4069	CDD:290274
		RCC1	4057..4106	CDD:278826
		RCC1 3-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4058..4108
		RCC1 3-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4110..4162
		RCC1	4110..4160	CDD:278826
		RCC1	4163..4212	CDD:278826
		RCC1 3-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4164..4214
		RCC1	4215..4263	CDD:278826
		RCC1 3-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4216..4266
		RCC1	4267..4316	CDD:278826
		RCC1 3-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4268..4318
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4804..4834

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820