DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and RCC1L

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_110425.2	Gene:	RCC1L / 81554	HGNCID:	14948	Length:	464	Species:	Homo sapiens

Alignment Length:	272	Identity:	68/272 - (25%)
Similarity:	100/272 - (36%)	Gaps:	80/272 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CGSHINVAISSENCVYSIPSCLHQFSERQFRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLA 209
            ||..:     .||.:||....:|:..:...:|.|:.||.:|::.|...|:|::.|.|..||.||.
Human   206 CGRKV-----VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLG 265

  Fly   210 ELRVEETPQLLEA-LAGIKITQIAAGGWHSAAISAFGDLYTWG---------------------- 251
            ...:..:|..|.. |||:.:.|:|..|....|:||.|.|:.||
Human   266 HYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL 330

  Fly   252 --------------------LNCSGQL---GLRVMKPGGVLKE--------PTVFPLPQLQDLPE 285
                                ||..|.:   |..::..|..|.|        ||:|.|.:..  ||
Human   331 HFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFN--PE 393

  Fly   286 CACSQSGESNDDCAPLRVFAGSRHTLLIRRCGRLWVSGWCKHGQLG-RQLQDLSYVDAFQALEGI 349
            ...|            |:..|..|...:...|.|:|.|....|.|| .:|:|..:.      ..:
Human   394 IQVS------------RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP------WRV 440

  Fly   350 TMNPTVDDVLCG 361
            ||.....||.||
Human   441 TMPGEPVDVACG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	68/272 (25%)
		RCC1_2	176..205	CDD:290274	10/28 (36%)
		RCC1	192..241	CDD:278826	16/49 (33%)
		RCC1_2	228..257	CDD:290274	12/70 (17%)
RCC1L	NP_110425.2	RCC1 1. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	58..124
		RCC1 2. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	128..191
		RCC1	130..189	CDD:278826
		RCC1_2	176..205	CDD:290274
		RCC1 3. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	193..247		13/45 (29%)
		RCC1	195..245	CDD:278826	12/43 (28%)
		RCC1_2	232..261	CDD:290274	10/28 (36%)
		RCC1 4. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	248..300		17/51 (33%)
		RCC1	248..298	CDD:278826	16/49 (33%)
		RCC1	301..351	CDD:278826	4/49 (8%)
		RCC1 5. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	302..353		5/50 (10%)
		RCC1 6. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	354..411		15/70 (21%)
		RCC1_2	396..425	CDD:290274	8/40 (20%)
		RCC1 7. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	412..461		15/47 (32%)
		RCC1	412..455	CDD:278826	15/47 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910