DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and herc5.2

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	303	Identity:	82/303 - (27%)
Similarity:	121/303 - (39%)	Gaps:	68/303 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GNIRALAAADSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIE 141
            |.:..|...|..|   .|.|:|.::..|.:.                                |.
Zfish    53 GKVSVLRLRDEDC---NQDGKLKQLDLKREK--------------------------------IR 82

  Fly   142 HIACGSHINVAISSENCV-----YSIPSCLHQFSERQFRVKQLQCGHEHAVLLNANGDVFTWGNG 201
            .|.||....|.::....|     |::  |.........:|.|:.||.:|:|.|:.:|.:|.||..
Zfish    83 SIVCGEDGAVLLADGGKVLLMDKYTV--CRPLKGLDNTKVIQIACGDQHSVALSNDGQLFVWGEN 145

  Fly   202 LRGQLGL-AELRVEETPQLLEALAGIKITQIAAGGWHSAAISAFGDLYTWGLNCSGQLGLRVMKP 265
            ..||||| .|..:.::||.|::|.||.:.||:|||.||..:|..|.::.||.|.:|||||
Zfish   146 AHGQLGLRKEQALIQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGL----- 205

  Fly   266 GGVLKEPTVFPLPQLQDLPECACSQSGESNDDCAPLRVFAGSRHTLLIRRCGRLWVSGWCKHGQL 330
             |...:..|         |....|.||:..     :.:..|..||..:.:.|.::..|....|||
Zfish   206 -GDTTDRFV---------PTIVKSLSGKKT-----VSISCGGEHTATLSKGGTVFTFGSGGFGQL 255

  Fly   331 G-RQLQDLSYVDAFQALEGITMNPTVDDVLCGPWSTLLHLKCT 372
            | ..|:|..:......|.|    ..|..|.||...||:.:..|
Zfish   256 GHNSLKDEHHPRLVAELWG----SKVSQVTCGRHHTLVLVALT 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	80/299 (27%)
		RCC1_2	176..205	CDD:290274	11/28 (39%)
		RCC1	192..241	CDD:278826	23/49 (47%)
		RCC1_2	228..257	CDD:290274	12/28 (43%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	11/28 (39%)
		RCC1	136..186	CDD:278826	23/49 (47%)
		RCC1	189..238	CDD:278826	18/68 (26%)
		RCC1	242..290	CDD:278826	16/51 (31%)
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058
		HECTc	678..984	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920