DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and Herc6

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_080268.1	Gene:	Herc6 / 67138	MGIID:	1914388	Length:	1003	Species:	Mus musculus

Alignment Length:	326	Identity:	87/326 - (26%)
Similarity:	142/326 - (43%)	Gaps:	68/326 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TGNIRALAAA--DSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSP 138
            |..|..|.||  :.|.|:|..:.::|........:|       ..|.:..|:|         ..|
Mouse    19 TSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQL-------GQRRDQSTER---------PEP 67

  Fly   139 I-------IEHIACGSHINVAISSENCVYSIPS------CLHQFSERQF-----------RVKQL 179
            |       ::.::||...:||:..:..|::..:      .:.:|.|..|           ::.|:
Mouse    68 IQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQV 132

  Fly   180 QCGHEHAVLLNANGDVFTWGNGLRGQLGLAE-LRVEETPQLLEALAGIKITQIAAGGWHSAAISA 243
            .|||.|::.|:.:|.||:||....|||||.: .|.:..||.:::|.||.:.|:||||.||.|:|.
Mouse   133 SCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSL 197

  Fly   244 FGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFP--LPQLQDLPECACSQSGESNDDCAPLRVFAG 306
            .|..:.||.|.||||.|    .|..:||....|  :..|::|               :.:.:..|
Mouse   198 TGTSFGWGSNRSGQLAL----SGNKVKEQIYKPHSIGALKNL---------------SVIYISCG 243

  Fly   307 SRHTLLIRRCGRLWVSGWCKHGQLGRQLQDLSYVDAFQALEGITMNPTVDDVLCGPWSTLLHLKC 371
            ..||.::...|:::..|....|||  |....|.....|.:|||  ...|..:.|..:.|:.::..
Mouse   244 YEHTAVLTEEGQVFTFGGNSSGQL--QPSPRSGQRGPQLIEGI--GGRVSQIECASYHTIAYVYT 304

  Fly   372 T 372
            |
Mouse   305 T 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	85/321 (26%)
		RCC1_2	176..205	CDD:290274	11/28 (39%)
		RCC1	192..241	CDD:278826	23/49 (47%)
		RCC1_2	228..257	CDD:290274	14/28 (50%)
Herc6	NP_080268.1	RCC1 1	40..91		11/66 (17%)
		RCC1	40..89	CDD:278826	10/64 (16%)
		RCC1 2	92..144		10/51 (20%)
		RCC1	92..142	CDD:278826	9/49 (18%)
		RCC1	145..195	CDD:278826	23/49 (47%)
		RCC1 3	146..197		24/50 (48%)
		RCC1_2	183..211	CDD:290274	14/27 (52%)
		RCC1 4	199..252		18/71 (25%)
		RCC1_2	237..266	CDD:290274	5/28 (18%)
		RCC1 5	253..303		14/53 (26%)
		RCC1	253..300	CDD:278826	14/50 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281		6/21 (29%)
		chaperonin_like	<570..>652	CDD:295468
		HECTc	658..999	CDD:238033
		HECTc	682..999	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920