DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6678 and ALS2

DIOPT Version :9

Sequence 1:NP_650996.1 Gene:CG6678 / 42581 FlyBaseID:FBgn0038917 Length:373 Species:Drosophila melanogaster
Sequence 2:NP_065970.2 Gene:ALS2 / 57679 HGNCID:443 Length:1657 Species:Homo sapiens


Alignment Length:252 Identity:62/252 - (24%)
Similarity:97/252 - (38%) Gaps:62/252 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LNAPVSTQN--------QCTISIGWRYAALAFGRKLCLRGLLD-DGPNECVTLEATGN--IRALA 83
            |::|.:|..        .|..::|.|.||......|.|:.::: .....|.|....|:  |....
Human   381 LHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGPEG 445

  Fly    84 AADSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEHIACGSH 148
            ..||....:.|..    :|.|..:.||.:|.|   .:..|::|                      
Human   446 LKDSREEQVKQES----MQGKKSSSLVDIREE---ETEGGSRR---------------------- 481

  Fly   149 INVAISSENCVYSIPSCLHQFSERQFR-----------VKQLQCGHEHAVLLNANGDVFTWGNGL 202
                       .|:|..|.|.|.|..|           :.....|...|:|.:...:|:|||.|.
Human   482 -----------LSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGK 535

  Fly   203 RGQLGLAELRVEETPQLLEALAGIKITQIAAGGWHSAAISAFGDLYTWGLNCSGQLG 259
            .||||..::.....|..::.|.|.::..:.|||:||.|::|...:|:||.|..||||
Human   536 EGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6678NP_650996.1 ATS1 <78..371 CDD:227511 49/195 (25%)
RCC1_2 176..205 CDD:290274 8/28 (29%)
RCC1 192..241 CDD:278826 17/48 (35%)
RCC1_2 228..257 CDD:290274 11/28 (39%)
ALS2NP_065970.2 RCC1 1. /evidence=ECO:0000305 59..108
RCC1_2 93..122 CDD:290274
RCC1 2. /evidence=ECO:0000305 109..167
RCC1 109..165 CDD:278826
RCC1 3. /evidence=ECO:0000305 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..480 13/54 (24%)
RCC1 4. /evidence=ECO:0000305 525..576 18/50 (36%)
RCC1 527..574 CDD:278826 17/46 (37%)
RCC1 5. /evidence=ECO:0000305 578..627 8/15 (53%)
RCC1 579..625 CDD:278826 8/14 (57%)
RhoGEF 695..879 CDD:295373
PH_alsin 905..1010 CDD:241423
PH 926..1004 CDD:278594
COG4642 1049..1188 CDD:226989
MORN 1 1049..1071
MORN 1049..1069 CDD:280628
MORN 2 1072..1094
MORN 3 1100..1122
MORN 1100..1120 CDD:280628
MORN 4 1123..1145
MORN 5 1151..1173
MORN 6 1175..1197
MORN 7 1198..1220
MORN 8 1221..1244
VPS9 1554..1653 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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