DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and herc4

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	365	Identity:	94/365 - (25%)
Similarity:	140/365 - (38%)	Gaps:	105/365 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WRYAALAFGRKLCLRGLLDD---GPNECVTLEATGNIRALAAADSHCLVLLQSGQLYRVQPKLQA 107
            |..|  :|| :|.|.|:.::   .|..|...|.. .:|.:.....|.:.||:.|.:|........
Zfish     4 WGNA--SFG-QLGLGGIDEEVLLEPRRCEFFEGK-RVRDVGCGRRHTVFLLEDGTVYTCGCNDLG 64

  Fly   108 ELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEHIACGSHINVAISSENCVYSIPSCLHQFSER 172
            :|                    |..||...|  |.:       |::.::|.|
Zfish    65 QL--------------------GHEKARKKP--EQV-------VSLDAQNIV------------- 87

  Fly   173 QFRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAE----LRVEETPQLLEALAGIKITQIAA 233
                 .:.||..|.:.||..|.||.||.|..|||||:.    |||   |:.:::|:.:.|||:|.
Zfish    88 -----AVSCGEAHTLALNDKGQVFAWGLGSDGQLGLSIVEDCLRV---PRTVKSLSEVHITQVAC 144

  Fly   234 GGWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLPECACSQSGE----- 293
            |.|||.|::..|::::||.|..|||||.  :.|..:..|.|  :..||.:|....|..|.
Zfish   145 GYWHSLALARGGEIFSWGQNKYGQLGLG--QQGACVCSPQV--IQSLQGIPFGQISAGGAHSFGL 205

  Fly   294 --------------------SNDD------CAPLR------VFAGSRHTLLIRRCGRLWVSGWCK 326
                                .|||      ...||      :..|..||..:.:.|.::..|...
Zfish   206 TLSGAIFGWGRNKFGQLGLGDNDDRRFPVLLKTLRSQQVVYICCGEDHTAALTKEGGVFTFGAGG 270

  Fly   327 HGQLGRQLQDLSYVDAFQALEGITMNPTVDDVLCGPWSTL 366
            :||||....: ..|:..:..|  .|...|..:.||...||
Zfish   271 YGQLGHNSTN-HEVNPRKVFE--LMGSVVSQIACGRQHTL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	84/330 (25%)
		RCC1_2	176..205	CDD:290274	11/28 (39%)
		RCC1	192..241	CDD:278826	24/52 (46%)
		RCC1_2	228..257	CDD:290274	13/28 (46%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826	12/48 (25%)
		RCC1	52..99	CDD:278826	14/93 (15%)
		RCC1	102..152	CDD:278826	24/52 (46%)
		RCC1	156..205	CDD:278826	17/52 (33%)
		RCC1	208..257	CDD:278826	8/48 (17%)
		RCC1	260..308	CDD:278826	14/51 (27%)
		RCC1	313..377	CDD:278826
		HECTc	704..1049	CDD:238033
		HECTc	730..1049	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920