DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6678 and NEK8

DIOPT Version :9

Sequence 1:NP_650996.1 Gene:CG6678 / 42581 FlyBaseID:FBgn0038917 Length:373 Species:Drosophila melanogaster
Sequence 2:NP_835464.1 Gene:NEK8 / 284086 HGNCID:13387 Length:692 Species:Homo sapiens


Alignment Length:438 Identity:90/438 - (20%)
Similarity:136/438 - (31%) Gaps:153/438 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 CVTLEATGNIRALAAADSHCLVL-LQSG------------------QLYRVQP------------ 103
            ||..|.....||..||:...||| :.||                  .|..::|            
Human   191 CVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQ 255

  Fly   104 --------KLQAELVAVRLEAAPR----SNSGTKRSIFGAAKAPSSPI----------------- 139
                    .|..::.:||:..|.:    ||:|::.:.......|..|:                 
Human   256 PLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGG 320

  Fly   140 -------------IEHIACG--SHINVAISSENCVYSI-------------------PSCLHQFS 170
                         :..:|.|  ....|..|....::..                   |..:.:|.
Human   321 LGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFL 385

  Fly   171 ERQ--FRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAELRVEETPQLLEALAGIKITQIAA 233
            |.|  ..:|.:.||......|...|.:.|:|:|..|.||...|.....|.::|||.|.::.|:|.
Human   386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVAC 450

  Fly   234 GGWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLPECAC---------- 288
            |..|..|:|...:|:.||...||:|||...:....   |...|:|..|:.....|          
Human   451 GASHVLALSTERELFAWGRGDSGRLGLGTRESHSC---PQQVPMPPGQEAQRVVCGIDSSMILTV 512

  Fly   289 --------------------------------------SQSGESNDDCAP-LRVFAGSRHTLLIR 314
                                                  :..|.:..|..| |.:..|:.|:..:.
Human   513 PGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVT 577

  Fly   315 RCGRLWVSGWCKHGQLGRQLQDLSYVDA-FQALEGITMNPTVDDVLCG 361
            ..|..:..|..:|||||...:..|.... .|.||||.|..    |.||
Human   578 ASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAM----VACG 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6678NP_650996.1 ATS1 <78..371 CDD:227511 87/430 (20%)
RCC1_2 176..205 CDD:290274 8/28 (29%)
RCC1 192..241 CDD:278826 17/48 (35%)
RCC1_2 228..257 CDD:290274 10/28 (36%)
NEK8NP_835464.1 STKc_Nek8 3..258 CDD:270859 14/66 (21%)
RCC1 276..657 CDD:332518 73/353 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..301 5/23 (22%)
RCC1 1 312..350 3/37 (8%)
RCC1 2 410..461 19/50 (38%)
RCC1 3 462..513 13/53 (25%)
RCC1 4 580..631 17/46 (37%)
RCC1 5 632..684
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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