DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and nekl-1

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001293320.1	Gene:	nekl-1 / 189769	WormBaseID:	WBGene00021461	Length:	983	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	77/384 - (20%)
Similarity:	134/384 - (34%)	Gaps:	89/384 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QHECVSGDVDCAAGFS---ELNAPVSTQNQCTISIGWRYAALAFGRKLCLRGLLDDGPNECVTLE 74
            :|...||.:..:..|:   :|:.|..|.:.                       :.|.|:..
Worm   430 RHRHTSGSMRSSVSFTTLYDLHVPTITLSS-----------------------IPDLPSRI---- 467

  Fly    75 ATGNIRALAAADSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPI 139
               :|:.:|.:.:|.:||....:|:........:|...:.  :...|.....|:.|..
Worm   468 ---SIKQVALSKTHTMVLTNDNELFGFGDNSCGQLGFGKF--SKMENGRLVESLKGRD------- 520

  Fly   140 IEHIACGSHINVAISSENCVYSI-----------------PSCLHQFSERQFRVKQLQCGHEHAV 187
            |:.:..|::.:|.......:.:.                 |..|.|....  .:|.:.|||:|.|
Worm   521 IQSVGVGNYFSVICCDRGTLLTFGTAKNLGLGKDAKDSAKPMLLEQLLRE--NIKDIYCGHDHVV 583

  Fly   188 LLNANGDVFTWGNGLRGQLGLAELRVEETPQLLEALAGIKITQIAAGGWHSAAISAFGDLYTWGL 252
            .:..:|:...||:...|||||..|.....|..:...:..||....||...:..:|..|.|...|.
Worm   584 AVLESGECLGWGSNQYGQLGLPTLEHFFAPTKIPMPSNKKIVYGKAGKDATMLLSDDGSLIAMGS 648

  Fly   253 NCSGQLGL--RV-------MKPGGVLKEPTVFPLPQLQDLPECACSQSGESNDDCAPLRVFAGSR 308
            |...:|.|  ||       ..|...:.:||:     ||..||.....|             .||.
Worm   649 NKHNKLNLTQRVGFFTKEKKTPNDYVNKPTI-----LQGFPERVVDFS-------------VGSY 695

  Fly   309 HTLLIRRCGRLWVSGWCKHGQLGRQLQDLSYVDAFQALEGITMNPTVDDVLCGPWSTLL 367
            |:.:|...|::.:.|...:.:||........|...:.::.: ::.....||||...||:
Worm   696 HSGVILESGQVMIFGRNDNTELGLGNSQKMAVRCVKPVKSL-LHHACTHVLCGDGFTLV 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	68/316 (22%)
		RCC1_2	176..205	CDD:290274	9/28 (32%)
		RCC1	192..241	CDD:278826	14/48 (29%)
		RCC1_2	228..257	CDD:290274	8/28 (29%)
nekl-1	NP_001293320.1	STKc_Nek	170..423	CDD:270855
nekl-1	NP_001293320.1	ATS1	449..764	CDD:227511	73/365 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010