DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and ran-3

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_495753.1	Gene:	ran-3 / 174332	WormBaseID:	WBGene00004304	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	372	Identity:	77/372 - (20%)
Similarity:	126/372 - (33%)	Gaps:	105/372 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SELNAPVSTQNQCTIS-IGWRYAALAFGRKLCLRG-LLDDGPNECVTLEATGNIRAL--AAADSH 88
            ::|.||:.|.:....| ||.|..:...|..|...| .....|.:....|..| ::.|  .|...|
Worm   133 AKLVAPLLTYDLFAPSIIGDRVLSCGEGEALGHPGRTTTKKPRKVDIFEEEG-LKPLQAVAGGVH 196

  Fly    89 CLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEH------IACGS 147
            ..||...|::|.....   |...|..|...:..|..:     .||......||.      :|.|:
Worm   197 SAVLTSEGEVYMCGIN---EKGTVPAEGVEKEGSTDE-----FAKVKFEEDIEKEGKIVMLAAGA 253

  Fly   148 HINVAISSENCVYS------------IPSCLHQFSE--------RQFRVKQLQCGHEHAVLLNAN 192
            ....|::.:..|.:            :...||:..|        .:.::.::..|..|.|:|:..
Worm   254 SFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKIAAGENHLVMLDEK 318

  Fly   193 GDVFTWGNGLRGQLG---------------------LAELRVEETPQLLEALAGIKITQIAAGGW 236
            |.:.|:|:|..||||                     |..||.:...:..:.:|    ..:.|.|:
Worm   319 GCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKGKFFDVVA----KNVFASGF 379

  Fly   237 HSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLPECACSQSGESNDDCAPL 301
            .:......|..|.:|||...|||::|                     .|....|.|:.|.:   |
Worm   380 WTIVHGEDGKYYAFGLNNYAQLGIKV---------------------DEADVGQDGQDNRE---L 420

  Fly   302 RVF-----------------AGSRHTLLIRRCGRLWVSGWCKHGQLG 331
            |||                 .|.:|.:::...|:::..|......||
Worm   421 RVFLPAEAPAFGAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALG 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	63/320 (20%)
		RCC1_2	176..205	CDD:290274	8/28 (29%)
		RCC1	192..241	CDD:278826	14/69 (20%)
		RCC1_2	228..257	CDD:290274	7/28 (25%)
ran-3	NP_495753.1	ATS1	163..569	CDD:227511	68/342 (20%)
		RCC1_2	189..215	CDD:290274	7/28 (25%)
		RCC1_2	246..276	CDD:290274	4/29 (14%)
		RCC1_2	302..331	CDD:290274	8/28 (29%)
		RCC1	510..565	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910