DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and nek8

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	458	Identity:	93/458 - (20%)
Similarity:	146/458 - (31%)	Gaps:	178/458 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 CVTLEATGNIRALAAADSHCLVL-LQSGQLY----RVQPKLQ---------------------AE 108
            ||..|.....||..||:...||| :.||...    |..|:|:                     |.
Zfish   191 CVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNEIMAH 255

  Fly   109 LVAVR-----------------------LEAAPRSNSG----TKRSIFGAAKAPSS------PII 140
            .:.:|                       ::|.|....|    :.|:..|.:...||      |:.
Zfish   256 AICIRPLLNLYTDIGNVKMRRIEKPLSNVQAGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLF 320

  Fly   141 EHIACGSHINV-----AISSENCVYSI-------------------------------------P 163
            .....||.|:.     .:::|....|:                                     |
Zfish   321 SVYTWGSGISTPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQP 385

  Fly   164 SCLHQFSERQ--FRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAELRVEETPQLLEALAGI 226
            ..:.:|.|.|  ..:|.:.||......|...|.:.|:|:|..|.||.........|:::|||.|.
Zfish   386 QFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGY 450

  Fly   227 KITQIAAGGWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLP------- 284
            ::.|::.|..|..|::...::::||...:|:|||.......         .||...||
Zfish   451 ELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHN---------CPQQVSLPADFEAQR 506

  Fly   285 -----EC-----------AC-------------SQSGESNDDC-------------APLR----- 302
                 :|           ||             |.:.|.:..|             |||.
Zfish   507 VLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIV 571

  Fly   303 -VFAGSRHTLLIRRCGRLWVSGWCKHGQLG---RQLQDLSYVDAFQALEGITMNPTVDDVLCGPW 363
             :..|:.|::.:...|:.:..|..:|||||   |:...:.|  ....|:||||      ..||..
Zfish   572 YIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPY--QVSGLQGITM------AACGDA 628

  Fly   364 STL 366
            .||
Zfish   629 FTL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	90/450 (20%)
		RCC1_2	176..205	CDD:290274	8/28 (29%)
		RCC1	192..241	CDD:278826	15/48 (31%)
		RCC1_2	228..257	CDD:290274	6/28 (21%)
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859	16/66 (24%)
		S_TKc	4..255	CDD:214567	15/63 (24%)
		ATS1	309..662	CDD:227511	71/340 (21%)
		RCC1 1	417..468		16/50 (32%)
		RCC1 2	469..520		11/59 (19%)
		RCC1 3	521..586		10/64 (16%)
		RCC1 4	587..636		18/53 (34%)
		RCC1 5	637..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010