DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and Herc2

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001347009.1	Gene:	Herc2 / 15204	MGIID:	103234	Length:	4836	Species:	Mus musculus

Alignment Length:	327	Identity:	75/327 - (22%)
Similarity:	122/327 - (37%)	Gaps:	127/327 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IGWRYAALAFGRKLCLRGLLDDGPNECVTLEATGNIRALAAADSHCLVLLQSGQLYRVQPKLQAE 108
            |||:|.|...            ||.:|..|.:.| :..:|.|:...|:|.::|::|  .....::
Mouse   432 IGWKYYANVI------------GPIQCEGLASLG-VMQVACAEKRFLILSRNGRVY--TQAYNSD 481

  Fly   109 LVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEHIACGSHINVAISSENCVYSIPSCLHQFSERQ 173
            ::|.:|                         ::.:|..:.:.:|..|:
Mouse   482 MLAPQL-------------------------VQGLASRNIVKIAAHSD----------------- 504

  Fly   174 FRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAELRVEETPQLLEAL----AGIKITQIAAG 234
                    || |.:.|.|.|:|::||.|..|:||..:....|.|:::.|.    ||..:..||.|
Mouse   505 --------GH-HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACG 560

  Fly   235 GWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQLQDLPECACSQSGESNDDCA 299
            ..:||||:|.|:|||||....|:||                               .|.|.|:..
Mouse   561 STYSAAITAEGELYTWGRGNYGRLG-------------------------------HGSSEDEAI 594

  Fly   300 PLRVF-------------AGSRHTLLIRRCGRLWVSGWCKHGQLGR-------------QLQDLS 338
            |:.|.             :|...||.:...|::|..|...:|:|||             :||||.
Mouse   595 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLD 659

  Fly   339 YV 340
            .:
Mouse   660 VI 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	65/293 (22%)
		RCC1_2	176..205	CDD:290274	10/28 (36%)
		RCC1	192..241	CDD:278826	18/52 (35%)
		RCC1_2	228..257	CDD:290274	14/28 (50%)
Herc2	NP_001347009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..90
		RCC1 1-1	416..462		12/42 (29%)
		RCC1 1-2	463..513		13/102 (13%)
		ATS1	<494..787	CDD:227511	56/225 (25%)
		RCC1 1-3	514..569		20/54 (37%)
		RCC1 1-4	570..621		17/81 (21%)
		RCC1 1-5	624..675		11/38 (29%)
		RCC1 1-6	676..727
		RCC1 1-7	729..779
		Cyt-b5	1212..1283	CDD:365921
		MIB_HERC2	1871..1930	CDD:369043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2351..2376
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:371573
		SH3_15	2640..2697	CDD:375773
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2928..2947
		ATS1	2957..3323	CDD:227511
		RCC1 2-1	2959..3010
		RCC1 2-2	3011..3065
		RCC1 2-3	3066..3117
		RCC1 2-4	3119..3169
		RCC1 2-5	3172..3223
		RCC1 2-6	3225..3275
		RCC1 2-7	3276..3327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3479..3499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3517..3537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3604..3632
		RCC1 3-1	3953..4004
		RCC1 3-2	4006..4058
		ATS1	4025..4330	CDD:227511
		RCC1 3-3	4060..4110
		RCC1 3-4	4112..4164
		RCC1 3-5	4166..4216
		RCC1 3-6	4218..4268
		RCC1 3-7	4270..4320
		HECTc	4423..4794	CDD:238033
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4806..4836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820