DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and RCC1

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001041659.1	Gene:	RCC1 / 1104	HGNCID:	1913	Length:	452	Species:	Homo sapiens

Alignment Length:	275	Identity:	64/275 - (23%)
Similarity:	97/275 - (35%)	Gaps:	77/275 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PNECVTLEATGNIRALAAADSHCLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGA 131
            |.:.|..||.|         .|.:.|.:|||:|......:..|             |...|:.|:
Human    97 PEDVVQAEAGG---------MHTVCLSKSGQVYSFGCNDEGAL-------------GRDTSVEGS 139

  Fly   132 AKAPSSPIIEHIACGSHINVAISSENCVYSIPSCLHQFSERQFRVKQLQCGHEHAVLLNANGDVF 196
            ...|..                                .|.|.:|.|:..|..|...|..:|.||
Human   140 EMVPGK--------------------------------VELQEKVVQVSAGDSHTAALTDDGRVF 172

  Fly   197 TWGN--GLRGQLGLAE-LRVEETPQLLEALAGIKITQIAAGGWHSAAISAFGDLYTWGLNCSGQL 258
            .||:  ...|.:||.| ::....|  ::....:.:.::|:|..|...::|.|||||.|....|||
Human   173 LWGSFRDNNGVIGLLEPMKKSMVP--VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 235

  Fly   259 GLRVMKPGGVLKEPTVFP-------LPQLQDLPECACSQSGESNDDCAPLRVFAGSRHTLLIRRC 316
            |          :.|.:|.       |.:|. :|:|...:|..|.........|.|:..|..|...
Human   236 G----------RVPELFANRGGRQGLERLL-VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 289

  Fly   317 GRLWVSGWCKHGQLG 331
            |.::..|...:.|||
Human   290 GHVYGFGLSNYHQLG 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	59/264 (22%)
		RCC1_2	176..205	CDD:290274	10/30 (33%)
		RCC1	192..241	CDD:278826	13/51 (25%)
		RCC1_2	228..257	CDD:290274	10/28 (36%)
RCC1	NP_001041659.1	RCC1	66..113	CDD:278826	6/24 (25%)
		RCC1	116..165	CDD:278826	15/93 (16%)
		RCC1	168..218	CDD:278826	13/51 (25%)
		RCC1	221..286	CDD:278826	21/75 (28%)
		RCC1	289..340	CDD:278826	5/16 (31%)
		RCC1	343..386	CDD:278826
		RCC1	394..445	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910