DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6678 and herc2

DIOPT Version :9

Sequence 1:	NP_650996.1	Gene:	CG6678 / 42581	FlyBaseID:	FBgn0038917	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	XP_012813154.2	Gene:	herc2 / 100487407	XenbaseID:	XB-GENE-1012659	Length:	4848	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	78/347 - (22%)
Similarity:	128/347 - (36%)	Gaps:	132/347 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ELNAPVSTQN--QCTIS---IGWRYAALAFGRKLCLRGLLDDGPNECVTLEATGNIRALAAADSH 88
            :.::|.|.:.  |..||   :||:|.|..            .||.:|..|...| :..:|.|:..
Frog   419 QCSSPTSHKGALQEVISWGLLGWKYYANV------------SGPIQCEALANLG-VTQVACAEKC 470

  Fly    89 CLVLLQSGQLYRVQPKLQAELVAVRLEAAPRSNSGTKRSIFGAAKAPSSPIIEHIACGSHINVAI 153
            .|:|.::|:||              .:|...:..|.:             :::.:|..:.:.:|.
Frog   471 FLILSRNGKLY--------------TQAYNNNTLGPQ-------------LVQGLASRNIVKIAA 508

  Fly   154 SSENCVYSIPSCLHQFSERQFRVKQLQCGHEHAVLLNANGDVFTWGNGLRGQLGLAELRVEETPQ 218
            ..:.                          :|.:.|:|..::|:||.|..|:||..:....|.|:
Frog   509 HPDG--------------------------QHYLALSATSELFSWGCGDGGRLGHGDTVSLEEPK 547

  Fly   219 LLEALA----GIKITQIAAGGWHSAAISAFGDLYTWGLNCSGQLGLRVMKPGGVLKEPTVFPLPQ 279
            |:.||:    |.::..||.|..:||||:|.|:|||||....|:||
Frog   548 LVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRGNYGRLG-------------------- 592

  Fly   280 LQDLPECACSQSGESNDDCAPLRVF-------------AGSRHTLLIRRCGRLWVSGWCKHGQLG 331
                       .|.|.|...|:.|.             :|...||.:...|::|..|...:|:||
Frog   593 -----------HGSSEDQTVPMLVTGLKGLKVVDVSCGSGDAQTLSVTENGQVWSWGDGDYGKLG 646

  Fly   332 R-------------QLQDLSYV 340
            |             :||||..|
Frog   647 RGGSDGCKTPKLIEKLQDLDIV 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6678	NP_650996.1	ATS1	<78..371	CDD:227511	64/293 (22%)
		RCC1_2	176..205	CDD:290274	7/28 (25%)
		RCC1	192..241	CDD:278826	18/52 (35%)
		RCC1_2	228..257	CDD:290274	14/28 (50%)
herc2	XP_012813154.2	ATS1	<501..794	CDD:227511	54/225 (24%)
		Cyt-b5	1219..1291	CDD:395121
		MIB_HERC2	1879..1939	CDD:399589
		UBA_HERC2	2471..2518	CDD:270585
		Cul7	2566..2643	CDD:402903
		SH3_15	2651..2708	CDD:408152
		ZZ_HERC2	2718..2762	CDD:239084
		APC10-HERC2	2777..2922	CDD:176485
		ATS1	2968..3334	CDD:227511
		ATS1	4037..4342	CDD:227511
		HECTc	4435..4806	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920