DRSC/TRiP Functional Genomics Resources

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Protein Alignment dnd and SAR1B

DIOPT Version :10

Sequence 1:NP_650995.1 Gene:dnd / 42580 FlyBaseID:FBgn0038916 Length:179 Species:Drosophila melanogaster
Sequence 2:NP_057187.1 Gene:SAR1B / 51128 HGNCID:10535 Length:198 Species:Homo sapiens


Alignment Length:173 Identity:54/173 - (31%)
Similarity:87/173 - (50%) Gaps:12/173 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EKEARILLLGLDNAGKTTILKQLASEDITTVTPTAGFNIKSVAADGFKLNVWDIGGQWKIRPYWK 79
            :|..:::.||||||||||:|..|..:.:....||.....:.:...|.....:|:||..:.|..||
Human    23 KKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWK 87

  Fly    80 NYFANTDVLIYVIDCTDRTRLPEAGSELFEMLMDNRLKQVPVLIFANKQDMPDAMSAAEVAE--- 141
            ||....:.:::::||.|..||.|:..||..::.|..:..||:||..||.|.|:|:|...:.|   
Human    88 NYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFG 152

  Fly   142 ---------KMSLVQLQGRTWEIKACTAVDGTGLKEGMDWVCK 175
                     .:||.:|..|..|:..|:.:...|..||..|:.:
Human   153 LYGQTTGKGSISLKELNARPLEVFMCSVLKRQGYGEGFRWMAQ 195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dndNP_650995.1 Arl3 3..176 CDD:206721 54/173 (31%)
SAR1BNP_057187.1 Sar1 3..197 CDD:206645 54/173 (31%)
STAR, SAR1-N-terminal activation recruitment. Required for the activation by PREB and subsequent recruitment to ER membrane. /evidence=ECO:0000250|UniProtKB:Q9QVY3 3..5
Mediates recruitment to ER membranes. /evidence=ECO:0000250|UniProtKB:Q9QVY3 15..19
Blue background indicates that the domain is not in the aligned region.

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