DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Magi3

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001152826.1	Gene:	Magi3 / 99470	MGIID:	1923484	Length:	1476	Species:	Mus musculus

Alignment Length:	466	Identity:	87/466 - (18%)
Similarity:	149/466 - (31%)	Gaps:	202/466 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 MGI-TLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQ---HQSVGQLQR------- 559
            ||: .|::.|||..|           :...:||||:|.||||:|.|   |....:|.:
Mouse  1044 MGLFILRLAEDGPAI-----------KDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1097

  Fly   560 -MLREARGSVTFKIVPS---------------YRSAPPPCEIFVRAQFDYNPLDDELIPCAQAGI 608
             :||...|     ::|.               |...|||    :.:....:..::..:|..:..:
Mouse  1098 LLLRPGTG-----LIPDHGDWDTNSPSSSNVIYDEQPPP----LPSSHSASTFEESHVPATEDSL 1153

  Fly   609 SFQVGDILQIISKDDH--HWWQARLDTVGGSAGLIPSPELQEWRIACQTVDKT--KQEQVNCSIF 669
            :     .:||..|.:.  ...|.:..|:.||     .||::     .|:|.||  |::....|..
Mouse  1154 T-----RVQICEKAEELKDTVQEKKSTLNGS-----QPEMK-----YQSVHKTMSKKDPPRGSGH 1203

  Fly   670 GRK-----------------------------------------KKQCRDKYLAKHNAIFDTLDV 693
            |.|                                         |::.||:.|:....  ::...
Mouse  1204 GEKSRLKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLKSDPKEKSRDRSLSPRKG--ESKGR 1266

  Fly   694 VTYEEVVKVPVG-DPN-----------FQRKTLVLLGAH-------------------------- 720
            :|    :|...| |||           .|:|    :|.:
Mouse  1267 LT----IKAGSGQDPNRKDRGRSSSPKKQQK----IGGNSLSNTEGKLSEAGSRRAAGHPRDSTE 1323

  Fly   721 ---------GVGRRHIKNT----LISKYPDKYAYPIPHTTRPAK----------PEEENGR---- 758
                     ||.|:.:|.:    ..:|.|:|.:..:..|:.|:|          .|:|.|:
Mouse  1324 QLPDGREKSGVSRKDLKQSQPGKTRTKSPEKKSSKVDETSLPSKKTSSTAGRVVSEKEKGKKPTA 1388

  Fly   759 ---SYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILD-------VEPQA 813
               |...|.|.::.|     :.|:....|....|...|     |...:..:.|       ..||:
Mouse  1389 GETSRETVEHTQISA-----KQLKQEAQEKTALGNADD-----HKGRESEVTDRCRERAGCTPQS 1443

  Fly   814 LKILRTAEFTP 824
            ..:::.|..||
Mouse  1444 SSLVKKAPITP 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492	23/78 (29%)
		SH3_CASK	586..646	CDD:213014	9/61 (15%)
		Guanylate_kin	710..883	CDD:279019	31/178 (17%)
		GuKc	720..883	CDD:214504	28/168 (17%)
Magi3	NP_001152826.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:15652357	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:302627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266
		WW	297..329	CDD:197736
		WW	345..375	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000250	413..495
		PDZ	416..496	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..575
		PDZ	578..659	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..691
		PDZ	729..812	CDD:214570
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844
		PDZ_signaling	851..936	CDD:238492
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..966
		PDZ_signaling	1023..1101	CDD:238492	20/67 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1151		5/45 (11%)
		MIP-T3	<1166..>1431	CDD:287245	49/294 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1476		55/317 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900