DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and DLG5

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:791 Identity:152/791 - (19%)
Similarity:236/791 - (29%) Gaps:295/791 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   359 SLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGR---------CRDVLE 414
            ||..:...:.:||:.:...|.|:........||......|..|:.:..||         |.|..|
Human  1181 SLTPSTT
VSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSE 1245

  Fly   415 QLSSTSGGNSL---------GGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRV----- 465
             :.:|.|.|||         .....|.|.:::.:.|.          ..|.|.|.|...|     
Human  1246 -MRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPR----------YPRSVVGSERGSVSHSEC 1299

  Fly   466 TPPPMVPYLNGDELDNVEGGELQ----------------------HVTRVRLVQFQKNTDEPMGI 508
            :.||..| ||.|.|.:....:..                      :|...|.|:.||.: ||:||
Human  1300 STPPQSP-LNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGS-EPLGI 1362

  Fly   509 TLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIV 573
            ::...|.|...|:::..|.:.| ||.|..||::.|.||  :..:|..:.|..|...:...|..|:
Human  1363 SIVSGEKGGIYVSKVTVGSIAH-QAGLEYGDQLLEFNG--INLRSATEQQARLIIGQQCDTITIL 1424

  Fly   574 PSYR-------------------------------------------------SAPP-------- 581
            ..|.                                                 |.||        
Human  1425 AQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRI 1489

  Fly   582 ----------PCEIF-------------------------------------------------- 586
                      |..:|                                                  
Human  1490 AGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLD 1554

  Fly   587 -------------------VRAQFDYNP------------------LDDELIPCAQAGISFQVGD 614
                               ||.:..|.|                  |.|.|....|. :||:..|
Human  1555 VRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQE-LSFKKDD 1618

  Fly   615 ILQIISKDD-------HHW--WQARLDTVGGSAGLIPSPEL--QEW--RIACQTV------DKTK 660
            ||.:   ||       ..|  ||...:......|.|||..:  ||:  |::...|      .||.
Human  1619 ILYV---DDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTL 1680

  Fly   661 QEQVNCSIFGRKKKQCR------------DKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKT 713
            ......|.|.||.|..|            |.:.:....:|:....:.|:.|.||   |....|..
Human  1681 SAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKV---DCTALRPV 1742

  Fly   714 LVLLGAHGVGRRHIKNTLISKYPDKYA-YPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEY 777
            |:|    |.....:|..|:::.|.|:. .|:.......:..|...:...||            :|
Human  1743 LIL----GPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFV------------DY 1791

  Fly   778 LEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY-- 840
            .....|.|.   |.:.:|:.|..:.:..:||:.|.|::.|......|.|:||...|.::|.:.  
Human  1792 KRRSGHFDV---TTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRD 1853

  Fly   841 -----DGSLERLAKE----SEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSW 896
                 |...:|.:||    ::.|.|.|..:|...|....:|.....:...:::......|:|.  
Human  1854 PIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA-- 1916

  Fly   897 LYXQDSELECP 907
                     ||
Human  1917 ---------CP 1918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996
S_TKc 12..278 CDD:214567
L27 347..396 CDD:280918 8/36 (22%)
L27 406..462 CDD:280918 16/73 (22%)
PDZ_signaling 493..573 CDD:238492 25/79 (32%)
SH3_CASK 586..646 CDD:213014 23/155 (15%)
Guanylate_kin 710..883 CDD:279019 39/184 (21%)
GuKc 720..883 CDD:214504 36/174 (21%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142
Takusan 130..212 CDD:282652
TPR_MLP1_2 231..353 CDD:285204
COG1340 295..587 CDD:224259
FliJ 310..449 CDD:304890
BAR 417..601 CDD:299863
PDZ_signaling 620..707 CDD:238492
DegQ <702..771 CDD:223343
PDZ_signaling 722..790 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 9/44 (20%)
PDZ 1347..1429 CDD:214570 27/85 (32%)
dbPDZ_assoc 1427..1499 CDD:293216 4/71 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493 3/58 (5%)
PDZ 1499..1582 CDD:214570 5/82 (6%)
SH3_DLG5 1597..1659 CDD:212794 18/65 (28%)
GuKc 1732..1908 CDD:214504 42/197 (21%)
Guanylate_kin 1740..1907 CDD:279019 39/185 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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