Protein Alignment CASK and Mpp2

DIOPT Version :9

• Sequence 1: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Sequence 2: XP_008766350.1
• Gene: Mpp2 / 85275
• RGDID: 620014
• Length: 569
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 240/585 - (41%)
• Similarity: 338/585 - (57%)
• Gaps: 57/585 - (9%)

  Fly   338 ADEEAGI--EAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQFLQLFDRIAAT---VVTS 396
            :.|||.:  ||:|::||.|..:.:... |.:|...||.::....:....:..:|:..|   .|..
  Rat    18 SSEEAELRREAMQQVLDNLGSLPNATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRD 82

  Fly   397 NGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEE 461
            |......|.:....::.|| |||:.           ||.|:|..||.|:||.:||.||...|
  Rat    83 NNLELVQEILRDLAELAEQ-SSTAA-----------ELARILQEPHFQSLLETHDSVASKTY--- 132

  Fly   462 ALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHG 526
               .||||      ...||.....:......||:|..:|...|.:|:|.:: |.|..::|||:||
  Rat   133 ---ETPPP------SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHG 187

  Fly   527 GMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQF 591
            ||:.:|..|||||.|:|:||||| ......||.:||.|.|||..||:|||:....|.::||:..|
  Rat   188 GMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRSASGSVILKILPSYQEPHLPRQVFVKCHF 251

  Fly   592 DYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIAC--Q 654
            ||:|..|.||||.:||:.|..||:|||:::||.:|||| ....|||||||||..|:|.|.|.  :
  Rat   252 DYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQA-CHVEGGSAGLIPSQLLEEKRKAFVKR 315

  Fly   655 TVDKTKQEQVNC-SIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLG 718
            .::.|......| |:.|:|||  |..||...||.||..:::.||||.::    |.|:||||||:|
  Rat   316 DLELTPTSGTLCGSLSGKKKK--RMMYLTTKNAEFDRHELLIYEEVARM----PPFRRKTLVLIG 374

  Fly   719 AHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTH 783
            |.|||||.:||.||...||:|...:|:|:|..|..|..|:.|.|||..||.|||.|..|||:|.:
  Rat   375 AQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEY 439

  Fly   784 EDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY-------- 840
            |..:|||::|:||.:...||:.:|||.|||:|:||||||.||||||.||..:.:...
  Rat   440 EGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESG 504

  Fly   841 -------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
                   :..|.|..:||..:::.|||:|||::||:::..|...|:||::::.|.||||||||:|
  Rat   505 VSTKQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 569

  Fly   899  898
              Rat   570  569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	11/52 (21%)
		L27	406..462	CDD:280918	19/55 (35%)
		PDZ_signaling	493..573	CDD:238492	38/79 (48%)
		SH3_CASK	586..646	CDD:213014	34/59 (58%)
		Guanylate_kin	710..883	CDD:279019	86/187 (46%)
		GuKc	720..883	CDD:214504	78/177 (44%)
Mpp2	XP_008766350.1	L27	30..83	CDD:197794	11/52 (21%)
		L27	85..136	CDD:280918	21/68 (31%)
		PDZ_signaling	155..233	CDD:238492	38/79 (48%)
		SH3_MPP2	246..304	CDD:212970	34/58 (59%)
		Guanylate_kin	366..556	CDD:279019	86/189 (46%)
		GuKc	376..557	CDD:214504	78/180 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920