DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and CARD11

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_001311210.1 Gene:CARD11 / 84433 HGNCID:16393 Length:1154 Species:Homo sapiens


Alignment Length:1153 Identity:200/1153 - (17%)
Similarity:343/1153 - (29%) Gaps:509/1153 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PHIVELLETYSSEGMLYMVFEFMEGSDLCFEVV---RRAVAGFVYSEAVACHYMRQILEALRYCH 133
            |.:.:.:||...|            .|..:|.|   |..::.:: :.|....|:|| .:.:....
Human     6 PEMDDYMETLKDE------------EDALWENVECNRHMLSRYI-NPAKLTPYLRQ-CKVIDEQD 56

  Fly   134 ENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTR---------ETIETH---------- 179
            |:::|:..:.|:             |:...|..:.:..|:         |::|.:          
Human    57 EDEVLNAPMLPS-------------KINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTG 108

  Fly   180 --------------GRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQ 230
                          |..|..|::..||:..:...|..|      :....|..||..| ...:.|.
Human   109 KEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQMKAKD------LQRCELLARLRQL-EDEKKQM 166

  Fly   231 SVARGR-LSFEAPEWK-------------SISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDR 281
            ::.|.. |:|:...:|             .:..:..:|.|:....:....:::        :|.|
Human   167 TLTRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAV--------MRSR 223

  Fly   282 D-------------------KLQRTH---LADTVE---------ELKRYNARRKLKG-AVQAI-- 312
            |                   ||:|..   |.:.:|         ||:|.|...|.|. .:|:|  
Human   224 DLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQ 288

  Fly   313 AGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDM---- 373
            ||..::     .|:|..|....:.  |.:..:|..|.:   ::.||:||:....|:.|||.    
Human   289 AGKRSL-----PDSDKAILDILEH--DRKEALEDRQEL---VNRIYNLQEEARQAEELRDKYLEE 343

  Fly   374 -----LRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVL---EQLSSTSGGNSL--GGK 428
                 |:.:.|.:..:::.....||:..      .|.|.|.||..   ...:.|.....|  ..|
Human   344 KEDLELKCSTLGKDCEMYKHRMNTVMLQ------LEEVERERDQAFHSRDEAQTQYSQCLIEKDK 402

  Fly   429 YAKE-------------ELMRLLAA-PHMQALLH--SHD---------------VVARDVYGEEA 462
            |.|:             |::|..|. .::::.|.  |.|               ::::| :|:.:
Human   403 YRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQD-FGDAS 466

  Fly   463 LRVTPPPMVPYLNGDELD-------------------------NVEGGELQH----VTRVRLVQF 498
                     |..||.|.|                         |::|.:||.    ::..|...|
Human   467 ---------PRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDF 522

  Fly   499 Q------KNTD--------------------------------EPMG---ITLKMTEDG--RCIV 520
            |      :.||                                ||.|   |..:..||.  |..|
Human   523 QAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTV 587

  Fly   521 ARIMHGG--------------------MIHRQATLHVGD-----EIREIN--------------- 545
            ......|                    .||..::.|..:     ::.::|               
Human   588 EEDNDSGGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPS 652

  Fly   546 ----------GQPVQHQSV------GQLQRMLREARGSVTFKIVPSYRSAPPP---------CEI 585
                      |..|||.::      .||..:...||||....:.|...:....         .|.
Human   653 VTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEG 717

  Fly   586 FVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWR 650
            .:|.:....|||    .|                :|::.||      |:...:|.:         
Human   718 CIRGERQSVPLD----TC----------------TKEEAHW------TIQRCSGPV--------- 747

  Fly   651 IACQTVDKTKQEQVNCSIFGRKKKQCRDK--------YLAKHNAIFDTLDVVTY----EEVVKV- 702
                    |...:||...:.:..|...|.        |:..:..|...||..|.    ::||.| 
Human   748 --------TLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVR 804

  Fly   703 ----------------PVGD--------PNFQRKTLVLL----------------GAHGVGRRHI 727
                            |..|        |::.|...:||                |.|.. .|.:
Human   805 DTMYQDRHEWLCARVDPFTDHDLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHT-LRAL 868

  Fly   728 KNTLISKYPDKYAYPIPHTTRPAKPEEE------------------NGRSYYFVSHDEMMADIGA 774
            :|||                   :|||.                  .|:...|||..|       
Human   869 RNTL-------------------QPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRSE------- 907

  Fly   775 NEYLEYGTHEDA--MYGTKLDTIRR-------IHTEGKMAILDVEPQALKIL------------- 817
            |:|....::|..  :.|:.|.::.|       :.|| |...||.|.:..|.|             
Human   908 NKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTE-KQEELDPESELGKNLSLIPYSLVRAFYC 971

  Fly   818 ---RTAEFTPYVVFIAAPSLQNIADYDGSLE------RLAKESEMLRQ 856
               |...|||.|  :|...:|.:.:..|::|      .:....|.||:
Human   972 ERRRPVLFTPTV--LAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRR 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 52/317 (16%)
S_TKc 12..278 CDD:214567 38/255 (15%)
L27 347..396 CDD:280918 13/57 (23%)
L27 406..462 CDD:280918 17/91 (19%)
PDZ_signaling 493..573 CDD:238492 28/178 (16%)
SH3_CASK 586..646 CDD:213014 10/59 (17%)
Guanylate_kin 710..883 CDD:279019 43/212 (20%)
GuKc 720..883 CDD:214504 39/186 (21%)
CARD11NP_001311210.1 CARD_CARD11_CARMA1 22..107 CDD:260070 15/99 (15%)
Linker. /evidence=ECO:0000305|PubMed:31296852 111..128 2/16 (13%)
BAR <173..>257 CDD:299863 12/91 (13%)
GBP_C <252..418 CDD:303769 40/181 (22%)
coiled coil 387..398 CDD:293879 1/10 (10%)
coiled coil 407..418 CDD:293879 0/10 (0%)
Inhibitory domain (ID). /evidence=ECO:0000303|PubMed:31296852 450..666 30/225 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..626 28/175 (16%)
PDZ_signaling 680..752 CDD:238492 18/114 (16%)
SH3 777..839 CDD:302595 12/61 (20%)
NK <1009..1143 CDD:302627 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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