DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and CPK30

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_177612.2	Gene:	CPK30 / 843813	AraportID:	AT1G74740	Length:	541	Species:	Arabidopsis thaliana

Alignment Length:	503	Identity:	147/503 - (29%)
Similarity:	220/503 - (43%)	Gaps:	84/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML-KHPH 73
            |.|.|...:|:|.|.|...|..||:.:..|.|.:...|...:  :...|::||.||...| :||:
plant    57 DKYILGRELGRGEFGITYLCTDRETREALACKSISKRKLRTA--VDVEDVRREVTIMSTLPEHPN 119

  Fly    74 IVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDIL 138
            :|:|..||.....:::|.|..||.:|...:|.|.    .|:|..|....|.|.|.:|.||.|.::
plant   120 VVKLKATYEDNENVHLVMELCEGGELFDRIVARG----HYTERAAATVARTIAEVVRMCHVNGVM 180

  Fly   139 HRDVRPACALLATVDNSAPVKLGGFG-SAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGC 202
            |||::|...|.|....::.:|...|| |.:..||.|.|    ..||.|:||||||: :|.||...
plant   181 HRDLKPENFLFANKKENSALKAIDFGLSVLFKPGERFT----EIVGSPYYMAPEVL-KRNYGPEV 240

  Fly   203 DVWGAGVMLHVLLSGRLPFLG---SGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPH 264
            |||.|||:|::||.|..||..   .||.|  ::.||.|.|:...|..||.:||.||.:||..:..
plant   241 DVWSAGVILYILLCGVPPFWAETEQGVAL--AILRGVLDFKRDPWSQISESAKSLVKQMLEPDST 303

  Fly   265 HRLSITEVLDHPWIRDRDKLQRTHLADTV-EELKRYNARRKLKG----------AVQAIAGGTNM 318
            .||:..:|||||||::..|.....|.|.| ..||:::...:||.          ::|.:....||
plant   304 KRLTAQQVLDHPWIQNAKKAPNVPLGDIVRSRLKQFSMMNRLKKKALRVIAEHLSIQEVEVIRNM 368

  Fly   319 DPLYATDADMPITGATDEWADEEAG------------IEAVQRILD-----CLDDIYSLQDA--- 363
            ..|...|.|..|:     :.:..||            |:.:..:.|     |||  |....|
plant   369 FTLMDDDNDGKIS-----YLELRAGLRKVGSQLGEPEIKLLMEVADVNGNGCLD--YGEFVAVII 426

  Fly   364 HVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNG-RAPAAEAVGR-----CRDVLEQLSSTSGG 422
            |     |:.|..|....|....||:..:..:.|.. |....:.:|.     ..|::.::.:...|
plant   427 H-----LQKMENDEHFRQAFMFFDKDGSGYIESEELREALTDELGEPDNSVIIDIMREVDTDKDG 486

  Fly   423 -----------------NSLGGKYAKEELMRLLAAPHMQALLHSHDVV 453
                             .....:|::|....|.........:|.||.:
plant   487 KINYDEFVVMMKAGTDWRKASRQYSRERFKSLSLNLMKDGSMHLHDAL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	113/313 (36%)
		S_TKc	12..278	CDD:214567	102/270 (38%)
		L27	347..396	CDD:280918	13/56 (23%)
		L27	406..462	CDD:280918	9/70 (13%)
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK30	NP_177612.2	STKc_CAMK	58..316	CDD:270687	101/270 (37%)
CPK30	NP_177612.2	PTZ00184	353..497	CDD:185504	28/155 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910