DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and CPK19

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_176386.2	Gene:	CPK19 / 842490	AraportID:	AT1G61950	Length:	551	Species:	Arabidopsis thaliana

Alignment Length:	484	Identity:	137/484 - (28%)
Similarity:	226/484 - (46%)	Gaps:	70/484 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FDDV---YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML 69
            |:|:   |.|...:|:|.|.|...|....|.:.||.|.:...|...:.  ...|::||..|.|.|
plant    91 FEDIKEKYSLGRELGRGQFGITYICTEISSGKNFACKSILKRKLIRTK--DREDVRREIQIMHYL 153

  Fly    70 K-HPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCH 133
            . .|:|||:...|.....:::|.|..||.:|..::.:|.    .|||..|...:|.:::.::.||
plant   154 SGQPNIVEIKGAYEDRQSVHLVMELCEGGELFDKITKRG----HYSEKAAAEIIRSVVKVVQICH 214

  Fly   134 ENDILHRDVRPACALLATVDN-SAPVKLGGFGSAIQLPGTR--ETIETHGRVGCPHYMAPEVVTR 195
            ...::|||::|...||::.|. |:.:|...||.::.:...:  |.|     ||..:|:||||: :
plant   215 FMGVIHRDLKPENFLLSSKDEASSMLKATDFGVSVFIEEGKVYEDI-----VGSAYYVAPEVL-K 273

  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEWKSISANAKDLVMKML 259
            |.|||..|:|.|||:|::||.|..||.....: :.:.:.||.:.||:..|.|||.:|||||..||
plant   274 RNYGKAIDIWSAGVILYILLCGNPPFWAETDKGIFEEILRGEIDFESEPWPSISESAKDLVRNML 338

  Fly   260 AANPHHRLSITEVLDHPWIRD----RDKLQRTHLADTVEELKRYNARRK--------------LK 306
            ..:|..|.:..:||:|||||:    .||...:.:...:::|:..|..:|              ||
plant   339 KYDPKKRFTAAQVLEHPWIREGGEASDKPIDSAVLSRMKQLRAMNKLKKLAFKFIAQNLKEEELK 403

  Fly   307 GAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLR 371
            |.....|   |||    ||....||     :.:.::|:|.:...|...:....|:||.||.:...
plant   404 GLKTMFA---NMD----TDKSGTIT-----YDELKSGLEKLGSRLTETEVKQLLEDADVDGNGTI 456

  Fly   372 DML-------------RDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVL--EQLSSTSG 421
            |.:             |::.|.:..|.||:..:..::......|.:......|::  |.:|....
plant   457 DYIEFISATMNRFRVEREDNLFKAFQHFDKDNSGFISRQELETAMKEYNMGDDIMIKEIISEVDA 521

  Fly   422 GNSLGGKYAKEE---LMRLLAAPHMQALL 447
            .|.  |....:|   :|:..:..|...|:
plant   522 DND--GSINYQEFCNMMKSCSQSHQSKLV 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	104/325 (32%)
		S_TKc	12..278	CDD:214567	92/270 (34%)
		L27	347..396	CDD:280918	12/61 (20%)
		L27	406..462	CDD:280918	9/47 (19%)
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK19	NP_176386.2	STKc_CAMK	97..356	CDD:270687	91/270 (34%)
		Pkinase	98..357	CDD:278497	92/270 (34%)
		PTZ00184	393..538	CDD:185504	33/158 (21%)
		EFh	405..464	CDD:238008	17/70 (24%)
		EFh	477..537	CDD:238008	11/61 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910