DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and CDPK9

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_197748.1	Gene:	CDPK9 / 832424	AraportID:	AT5G23580	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	414	Identity:	133/414 - (32%)
Similarity:	204/414 - (49%)	Gaps:	43/414 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML-KHP 72
            :|.|.|.:|:|:|.|.....|.|:::.|:.|.|.:...|........  |:.||..|.|.| ::|
plant    19 EDNYFLGQVLGQGQFGTTFLCTHKQTGQKLACKSIPKRKLLCQEDYD--DVLREIQIMHHLSEYP 81

  Fly    73 HIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDI 137
            ::|.:...|.....:::|.|..||.:|...:|:|.    .|||..|...::.|:..:..||...:
plant    82 NVVRIESAYEDTKNVHLVMELCEGGELFDRIVKRG----HYSEREAAKLIKTIVGVVEACHSLGV 142

  Fly   138 LHRDVRPACALLATVDNSAPVKLGGFG-SAIQLPGTRETIETHGR-VGCPHYMAPEVVTRRLYGK 200
            :|||::|...|.::.|..|.:|...|| |....||     |.... ||..:|:||||:.:. ||.
plant   143 VHRDLKPENFLFSSSDEDASLKSTDFGLSVFCTPG-----EAFSELVGSAYYVAPEVLHKH-YGP 201

  Fly   201 GCDVWGAGVMLHVLLSGRLPFLG-SGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPH 264
            .||||.|||:|::||.|..||.. |.:.:.:.:.:|:|.||...|.|||.:||||:.|||.:||.
plant   202 ECDVWSAGVILYILLCGFPPFWAESEIGIFRKILQGKLEFEINPWPSISESAKDLIKKMLESNPK 266

  Fly   265 HRLSITEVLDHPWIRDRDKLQRTHLAD--TVEELKRYNARRKLKG-AVQAIA--------GGTNM 318
            .||:..:||.||||.| ||:......|  .|..||:::|..|||. |::.||        ||  :
plant   267 KRLTAHQVLCHPWIVD-DKVAPDKPLDCAVVSRLKKFSAMNKLKKMALRVIAERLSEEEIGG--L 328

  Fly   319 DPLY-ATDADMPITGATDEWADE---------EAGIEAVQRILDCLDDIYSLQDAHVDADV--LR 371
            ..|: ..|.|...|...:|..|.         |:.|:.:.|..| :|:..::......|..  |.
plant   329 KELFKMIDTDKSGTITFEELKDSMRRVGSELMESEIQELLRAAD-VDESGTIDYGEFLAATIHLN 392

  Fly   372 DMLRDNRLHQFLQLFDRIAATVVT 395
            .:.|:..|......||:.|:..:|
plant   393 KLEREENLVAAFSFFDKDASGYIT 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	109/305 (36%)
		S_TKc	12..278	CDD:214567	95/269 (35%)
		L27	347..396	CDD:280918	11/51 (22%)
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CDPK9	NP_197748.1	STKc_CAMK	21..279	CDD:270687	94/269 (35%)
		Pkinase	22..280	CDD:278497	95/269 (35%)
		PTZ00184	316..458	CDD:185504	23/104 (22%)
		EFh	328..387	CDD:238008	11/59 (19%)
		EFh	400..459	CDD:238008	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910