DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and CPK4

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_192695.1	Gene:	CPK4 / 826541	AraportID:	AT4G09570	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	451	Identity:	131/451 - (29%)
Similarity:	210/451 - (46%)	Gaps:	61/451 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHML-KHPH 73
            |.|.|.:.:|:|.|.....|..:.|:..:|.|.:...|........  |:.||..|.|.| :||:
plant    23 DHYLLGKKLGQGQFGTTYLCTEKSSSANYACKSIPKRKLVCREDYE--DVWREIQIMHHLSEHPN 85

  Fly    74 IVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDIL 138
            :|.:..||.....:::|.|..||.:|...:|.:.    .:||..|...::.||..:..||...::
plant    86 VVRIKGTYEDSVFVHIVMEVCEGGELFDRIVSKG----CFSEREAAKLIKTILGVVEACHSLGVM 146

  Fly   139 HRDVRPACALLATVDNSAPVKLGGFG-SAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGC 202
            |||::|...|..:..:.|.:|...|| |....||.    ..:..||.|:|:||||: ::.||...
plant   147 HRDLKPENFLFDSPSDDAKLKATDFGLSVFYKPGQ----YLYDVVGSPYYVAPEVL-KKCYGPEI 206

  Fly   203 DVWGAGVMLHVLLSGRLPFLG---SGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPH 264
            |||.|||:|::||||..||..   ||:..|  :.:|::.|::..|.:||..||||:.|||..:|.
plant   207 DVWSAGVILYILLSGVPPFWAETESGIFRQ--ILQGKIDFKSDPWPTISEGAKDLIYKMLDRSPK 269

  Fly   265 HRLSITEVLDHPWIRDRDKLQRTHLADTV-EELKRYNARRKLKG-AVQAIA--------GG-TNM 318
            .|:|..|.|.||||.|........|...| ..||:::...|:|. |::.||        || ..:
plant   270 KRISAHEALCHPWIVDEHAAPDKPLDPAVLSRLKQFSQMNKIKKMALRVIAERLSEEEIGGLKEL 334

  Fly   319 DPLYATDADMPITGATDEWADEEAGIEAV-QRILDCLDDIYSLQDAHVDADV------------- 369
            ..:..||....||     :.:.:||::.| ..:::  .:|.||.||   ||:
plant   335 FKMIDTDNSGTIT-----FEELKAGLKRVGSELME--SEIKSLMDA---ADIDNSGTIDYGEFLA 389

  Fly   370 ----LRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRC----RDVLEQLSSTSGG 422
                :..|.|:..|......||:..:..:|.:....|....|.|    .|:::::...:.|
plant   390 ATLHINKMEREENLVVAFSYFDKDGSGYITIDELQQACTEFGLCDTPLDDMIKEIDLDNDG 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	101/304 (33%)
		S_TKc	12..278	CDD:214567	91/270 (34%)
		L27	347..396	CDD:280918	13/66 (20%)
		L27	406..462	CDD:280918	4/21 (19%)
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK4	NP_192695.1	STKc_CAMK	24..282	CDD:270687	90/270 (33%)
CPK4	NP_192695.1	PTZ00184	319..461	CDD:185504	29/142 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910