DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and CPK21

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001319867.1	Gene:	CPK21 / 825807	AraportID:	AT4G04720	Length:	531	Species:	Arabidopsis thaliana

Alignment Length:	464	Identity:	130/464 - (28%)
Similarity:	223/464 - (48%)	Gaps:	69/464 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEIL---FDDV---YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKRE 62
            |.||   |:|:   |.|.:.:|:|.|.|...|....:...:|.|.:...|..:..  ...|:|||
plant    66 DTILGKPFEDIRKFYSLGKELGRGQFGITYMCKEIGTGNTYACKSILKRKLISKQ--DKEDVKRE 128

  Fly    63 ATICHMLK-HPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQIL 126
            ..|...|. .|:|||:...|.....:::|.|...|.:| |:   |.:|...|||..|...:|.|:
plant   129 IQIMQYLSGQPNIVEIKGAYEDRQSIHLVMELCAGGEL-FD---RIIAQGHYSERAAAGIIRSIV 189

  Fly   127 EALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGR-----VGCPH 186
            ..::.||...::|||::|...||::.:.:|.:|...||.::.:        ..|:     ||..:
plant   190 NVVQICHFMGVVHRDLKPENFLLSSKEENAMLKATDFGLSVFI--------EEGKVYRDIVGSAY 246

  Fly   187 YMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEWKSISAN 250
            |:||||: ||.|||..|:|.|||:|::||||..||.....: :...|.:|.:.|.:..|.|||.:
plant   247 YVAPEVL-RRSYGKEIDIWSAGVILYILLSGVPPFWAENEKGIFDEVIKGEIDFVSEPWPSISES 310

  Fly   251 AKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKG-AVQAIAG 314
            |||||.|||..:|..|::..:||:||||:..:...:...:..:..:|::.|..|||. |::.||.
plant   311 AKDLVRKMLTKDPKRRITAAQVLEHPWIKGGEAPDKPIDSAVLSRMKQFRAMNKLKKLALKVIAE 375

  Fly   315 GTN------MDPLYA---TDADMPITGATDEWADEEAGI---------EAVQRILDCLD------ 355
            ..:      :..::|   ||....||     :.:.:.|:         ..|:::::..|
plant   376 SLSEEEIKGLKTMFANIDTDKSGTIT-----YEELKTGLTRLGSRLSETEVKQLMEAADVDGNGT 435

  Fly   356 -DIYSLQDAHVDADVLRDML-RDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVG-----RCRDVL 413
             |.|..    :.|.:.|..| ||..:::..|.||:..:..:|.:....|.:..|     ..::|:
plant   436 IDYYEF----ISATMHRYKLDRDEHVYKAFQHFDKDNSGHITRDELESAMKEYGMGDEASIKEVI 496

  Fly   414 EQLSSTSGG 422
            .::.:.:.|
plant   497 SEVDTDNDG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	101/310 (33%)
		S_TKc	12..278	CDD:214567	92/272 (34%)
		L27	347..396	CDD:280918	12/56 (21%)
		L27	406..462	CDD:280918	3/22 (14%)
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK21	NP_001319867.1	STKc_CAMK	79..337	CDD:270687	91/272 (33%)
CPK21	NP_001319867.1	PTZ00184	373..518	CDD:185504	25/142 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910