DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and CPK13

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_190753.2	Gene:	CPK13 / 824348	AraportID:	AT3G51850	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	409	Identity:	120/409 - (29%)
Similarity:	197/409 - (48%)	Gaps:	47/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATIC-HMLKHP 72
            :|.|.|...:|:|.|.:...||.|.|....|.|.:...|...:  :...|:|||..|. |:.|..
plant    51 EDRYLLDRELGRGEFGVTYLCIERSSRDLLACKSISKRKLRTA--VDIEDVKREVAIMKHLPKSS 113

  Fly    73 HIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDI 137
            .||.|.|....:..:::|.|..||.:|...:|.|.    .|:|..|....:.|:|.::.||::.:
plant   114 SIVTLKEACEDDNAVHLVMELCEGGELFDRIVARG----HYTERAAAGVTKTIVEVVQLCHKHGV 174

  Fly   138 LHRDVRPACALLATVDNSAPVKLGGFGSAIQL-PGTRETIETHGRVGCPHYMAPEVVTRRLYGKG 201
            :|||::|...|.|....::|:|...||.:|.. ||.:.:    ..||.|:||||||: :|.||..
plant   175 IHRDLKPENFLFANKKENSPLKAIDFGLSIFFKPGEKFS----EIVGSPYYMAPEVL-KRNYGPE 234

  Fly   202 CDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHH 265
            .|:|.|||:|::||.|..||.....: :.|::.||.:.|:...|.:||..||:||.:||..:|..
plant   235 IDIWSAGVILYILLCGVPPFWAESEQGVAQAILRGVIDFKREPWPNISETAKNLVRQMLEPDPKR 299

  Fly   266 RLSITEVLDHPWIRDRDKLQRTHLADTVE-ELKRYNARRKLK-GAVQAIAGGTNMDPLYATDADM 328
            ||:..:||:||||::..|.....|.|.|: .||:::...:.| .|::.||      ...:|:...
plant   300 RLTAKQVLEHPWIQNAKKAPNVPLGDVVKSRLKQFSVMNRFKRKALRVIA------EFLSTEEVE 358

  Fly   329 PITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADV------------------------ 369
            .|....::...:..||.:::.:...|.| :|.|.|..:..:
plant   359 DIKVMFNKMDTDNDGIVSIEELKAGLRD-FSTQLAESEVQMLIEAVDTKGKGTLDYGEFVAVSLH 422

  Fly   370 LRDMLRDNRLHQFLQLFDR 388
            |:.:..|..|.:....||:
plant   423 LQKVANDEHLRKAFSYFDK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	103/303 (34%)
		S_TKc	12..278	CDD:214567	93/268 (35%)
		L27	347..396	CDD:280918	10/66 (15%)
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK13	NP_190753.2	STKc_CAMK	53..311	CDD:270687	92/268 (34%)
		FRQ1	352..493	CDD:227455	14/91 (15%)
		EFh_PEF	470..>526	CDD:355382
		EF-hand motif	470..497	CDD:320054
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910