DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and CPK9

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001327803.1	Gene:	CPK9 / 821586	AraportID:	AT3G20410	Length:	541	Species:	Arabidopsis thaliana

Alignment Length:	475	Identity:	142/475 - (29%)
Similarity:	232/475 - (48%)	Gaps:	56/475 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EILFDDV---YELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATIC 66
            |..|:||   |.|.:.:|:|.|.:...|....:.:::|.|.:...|....  ....|::||..|.
plant    81 ENAFEDVKLFYTLGKELGRGQFGVTYLCTENSTGKKYACKSISKKKLVTK--ADKDDMRREIQIM 143

  Fly    67 -HMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130
             |:...|:|||....|..|..:.:|.|...|.:| |:   |.:|...|:|..|....|||:..::
plant   144 QHLSGQPNIVEFKGAYEDEKAVNLVMELCAGGEL-FD---RIIAKGHYTERAAASVCRQIVNVVK 204

  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGR-----VGCPHYMAP 190
            .||...:||||::|...||::.|..|.:|...||.::.:        ..|:     ||..:|:||
plant   205 ICHFMGVLHRDLKPENFLLSSKDEKALIKATDFGLSVFI--------EEGKVYRDIVGSAYYVAP 261

  Fly   191 EVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVR-LQQSVARGRLSFEAPEWKSISANAKDL 254
            ||:.|| |||..|:|.||::|::||||..||.....: :..::..|.:.||:..|.|||::||||
plant   262 EVLRRR-YGKEVDIWSAGIILYILLSGVPPFWAETEKGIFDAILEGHIDFESQPWPSISSSAKDL 325

  Fly   255 VMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTV-EELKRYNARRKLKG-AVQAIAGGTN 317
            |.:||.|:|..|:|..:||.|||:|:..:.....:...| ..:|::.|..|||. |::.||  .|
plant   326 VRRMLTADPKRRISAADVLQHPWLREGGEASDKPIDSAVLSRMKQFRAMNKLKKLALKVIA--EN 388

  Fly   318 MD--------PLYAT-DADMPITGATDEWADEEAGI-----EA-VQRILDCLD-----DIYSLQD 362
            :|        .::|. |.|...|...:|..:..|.:     || |::::|..|     .|..::
plant   389 IDTEEIQGLKAMFANIDTDNSGTITYEELKEGLAKLGSKLTEAEVKQLMDAADVDGNGSIDYIE- 452

  Fly   363 AHVDADVLRDMLRDN-RLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRD--VLEQLSSTSGGNS 424
             .:.|.:.|..|..| .|::..|.||:.::..:|.:....|.:..|...|  :.|.||.....|.
plant   453 -FITATMHRHRLESNENLYKAFQHFDKDSSGYITIDELESALKEYGMGDDATIKEVLSDVDSDND 516

  Fly   425 LGGKYAKEELMRLLAAPHMQ 444
              |:...||...::.:.:.|
plant   517 --GRINYEEFCAMMRSGNPQ 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	104/311 (33%)
		S_TKc	12..278	CDD:214567	93/272 (34%)
		L27	347..396	CDD:280918	12/54 (22%)
		L27	406..462	CDD:280918	10/41 (24%)
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CPK9	NP_001327803.1	STKc_CAMK	90..348	CDD:270687	92/272 (34%)
CPK9	NP_001327803.1	FRQ1	388..528	CDD:227455	33/143 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910