DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and MAPKKK6

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_187455.1	Gene:	MAPKKK6 / 819989	AraportID:	AT3G07980	Length:	1367	Species:	Arabidopsis thaliana

Alignment Length:	1070	Identity:	235/1070 - (21%)
Similarity:	400/1070 - (37%)	Gaps:	273/1070 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPH 73
            |:.|.|.:.||||.:..|...:..|:....|:|.|.:... ....|:|  :.:|..:...|.|.:
plant    17 DNKYMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLENI-GQEDLNT--IMQEIDLLKNLNHKN 78

  Fly    74 IVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDIL 138
            ||:.|.:..::..|:::.|::|...|. .:::....| .:.|::...|:.|:||.|.|.||..::
plant    79 IVKYLGSLKTKTHLHIILEYVENGSLA-NIIKPNKFG-PFPESLVTVYIAQVLEGLVYLHEQGVI 141

  Fly   139 HRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGCD 203
            |||::.| .:|.|.:..  |||..||.|.:|  ......||..||.|::|||||:.........|
plant   142 HRDIKGA-NILTTKEGL--VKLADFGVATKL--NEADFNTHSVVGTPYWMAPEVIELSGVCAASD 201

  Fly   204 VWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFE--APEWKSISANAKDLVMKMLAANPHHR 266
            :|..|..:..||:...|:..    ||...|..|:..:  .|...|:|.:..|.:......:...|
plant   202 IWSVGCTIIELLTCVPPYYD----LQPMPALYRIVQDDTPPIPDSLSPDITDFLRLCFKKDSRQR 262

  Fly   267 LSITEVLDHPWIRDRDKLQRTHL--ADTVEELKR--YNARRKLKGAVQAIAGGTNMDPLYATDAD 327
            .....:|.|||||:..:..|:.|  :.|:..:|.  .::.:..:|: |.:....:.:.:..|..:
plant   263 PDAKTLLSHPWIRNSRRALRSSLRHSGTIRYMKETDSSSEKDAEGS-QEVVESVSAEKVEVTKTN 326

  Fly   328 ----MPITGAT------DEWADEEAGIEAVQRILDCLDDIYSLQ--------------------- 361
                :|:.|..      |:.:..:.|.|..    |..|||.|.|
plant   327 SKSKLPVIGGASFRSEKDQSSPSDLGEEGT----DSEDDINSDQGPTLSMHDKSSRQSGTCSISS 387

  Fly   362 DAH-VDADVLRDMLRDNRLHQFLQLFDRIAATVVT--SNGR--APAAEAVGRCRDVLEQLSSTSG 421
            ||. ...|||.:..:.:|        |.|...:.|  |.||  ..|.:.||:...:....|.:..
plant   388 DAKGTSQDVLENHEKYDR--------DEIPGNLETEASEGRRNTLATKLVGKEYSIQSSHSFSQK 444

  Fly   422 G-----------NSLGGKYAKEELMRLLAAP---HMQALLHSHDVVARDVYGEEALRVTPPPMVP 472
            |           :|.||    .||.|....|   .:..|.|..|.|......|.:   |..|...
plant   445 GEDGLRKAVKTPSSFGG----NELTRFSDPPGDASLHDLFHPLDKVPEGKTNEAS---TSTPTAN 502

  Fly   473 YLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHV 537
            ...||. ...:||:....|::|....||..:...|    .::||..:. |:|.|  :.:...|::
plant   503 VNQGDS-PVADGGKNDLATKLRARIAQKQMEGETG----HSQDGGDLF-RLMMG--VLKDDVLNI 559

  Fly   538 GD-----EIREINGQPVQHQSVGQLQRMLR--EARGSV---TFKIVPSYRSAPPPCEIFVRAQFD 592
            .|     ::...|..|:|.....:|...||  |:..::   :.|:|..:|..|....:|| .|..
plant   560 DDLVFDEKVPPENLFPLQAVEFSRLVSSLRPDESEDAIVTSSLKLVAMFRQRPGQKAVFV-TQNG 623

  Fly   593 YNPLDDEL-IP-----CAQAGISFQVGDILQIIS---KDDHHWWQ-ARLDTVGGSAGLIP----- 642
            :.||.|.| ||     ||          :||:|:   ||:..:.: |.|      .||||
plant   624 FLPLMDLLDIPKSRVICA----------VLQLINEIVKDNTDFLENACL------VGLIPLVMSF 672

  Fly   643 -------SPELQE-----WRIACQTVDKTKQEQVNC----------------------------- 666
                   |.|:::     .:..||:...|.|..::|
plant   673 AGFERDRSREIRKEAAYFLQQLCQSSPLTLQMFISCRGIPVLVGFLEADYAKHREMVHLAIDGMW 737

  Fly   667 SIFGRKKKQCRDKY--LAKHNAIFDTLDVVTY--EEVVKVP--VGDPNFQRKTLVLLG----AHG 721
            .:|..||...|:.:  :|..|.|...|....|  .|..::.  .||      .|:|.|    |..
plant   738 QVFKLKKSTSRNDFCRIAAKNGILLRLVNTLYSLSEATRLASISGD------ALILDGQTPRARS 796

  Fly   722 VGRRHIKNTLISK---YPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTH 783
             |:....|.:.|:   .|....:|....||....||.:    :.::.:...:|:...:.|    |
plant   797 -GQLDPNNPIFSQRETSPSVIDHPDGLKTRNGGGEEPS----HALTSNSQSSDVHQPDAL----H 852

  Fly   784 ED-------------------------AMYGTKLDTIRRIHTEGK---------------MAILD 808
            .|                         :...|..|.:::: .||.               :::|:
plant   853 PDGDRPRLSSVVADATEDVIQQHRISLSANRTSTDKLQKL-AEGASNGFPVTQPDQVRPLLSLLE 916

  Fly   809 VEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEM-----LRQLYGHFFDLT--- 865
            .||.:.||....::..::.        .|..::..|..|....|.     |..:...|.:::
plant   917 KEPPSRKISGQLDYVKHIA--------GIERHESRLPLLYASDEKKTNGDLEFIMAEFAEVSGRG 973

  Fly   866 IVNNDI-------SETIATLETAIDRVHTT 888
            ..|.::       |:|:.....||:||.:|
plant   974 KENGNLDTAPRYSSKTMTKKVMAIERVAST 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	82/304 (27%)
		S_TKc	12..278	CDD:214567	74/267 (28%)
		L27	347..396	CDD:280918	15/72 (21%)
		L27	406..462	CDD:280918	16/69 (23%)
		PDZ_signaling	493..573	CDD:238492	19/89 (21%)
		SH3_CASK	586..646	CDD:213014	23/81 (28%)
		Guanylate_kin	710..883	CDD:279019	36/234 (15%)
		GuKc	720..883	CDD:214504	32/220 (15%)
MAPKKK6	NP_187455.1	STKc_Cdc7_like	19..274	CDD:270797	74/268 (28%)
MAPKKK6	NP_187455.1	S_TKc	20..274	CDD:214567	74/267 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000