DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and CAMK2D

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001308498.1	Gene:	CAMK2D / 817	HGNCID:	1462	Length:	533	Species:	Homo sapiens

Alignment Length:	614	Identity:	192/614 - (31%)
Similarity:	277/614 - (45%)	Gaps:	146/614 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69
            |.|.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
Human    10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK------LSARDHQKLEREARICRLL 68

  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134
            |||:||.|.::.|.||..|:||:.:.|.:|..::|.|.    .||||.|.|.::||||::.:||.
Human    69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILESVNHCHL 129

  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199
            |.|:|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
Human   130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA--WFGFAGTPGYLSPEVLRKDPYG 192

  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
Human   193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 257

  Fly   264 HHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDAD 327
            ..|::.:|.|.||||..|..: ...|..:||:.||::|||||||||:        :..:.||
Human   258 AKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI--------LTTMLAT--- 311

  Fly   328 MPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAAT 392
                          ....|.:.:|...|.:..                :|:            |.
Human   312 --------------RNFSAAKSLLKKPDGVKI----------------NNK------------AN 334

  Fly   393 VVTS---NGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVA 454
            ||||   |...||.|.           .:|...|..|.|.:.|.         ....:...||.|
Human   335 VVTSPKENIPTPALEP-----------QTTVIHNPDGNKESTES---------SNTTIEDEDVKA 379

  Fly   455 RDVYGEEALRVTPPPMVPYLNGD------------------ELDN-VEGGELQHVTRVRLVQFQK 500
            |.   :|.::||...:....|||                  .|.| |||.:..   |........
Human   380 RK---QEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFH---RFYFENALS 438

  Fly   501 NTDEPMGITL------KMTEDGRCI----VARIMHG-GMIHRQATLHVGDEIREINGQPVQHQSV 554
            .:::|:...:      .:.:|..||    :.:.|.| ||   ..|:. .:|.|      |.|:..
Human   439 KSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGM---PKTMQ-SEETR------VWHRRD 493

  Fly   555 GQLQRMLREARGSVTFKIVPSYRSAPPPC 583
            |:.|.:.....||.|..|       .|||
Human   494 GKWQNVHFHRSGSPTVPI-------KPPC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	132/304 (43%)
		S_TKc	12..278	CDD:214567	115/269 (43%)
		L27	347..396	CDD:280918	6/48 (13%)
		L27	406..462	CDD:280918	9/55 (16%)
		PDZ_signaling	493..573	CDD:238492	18/90 (20%)
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	131/302 (43%)
CAMK2D	NP_001308498.1	CaMKII_AD	380..507	CDD:285524	29/142 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810