DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Mpp7

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_011245327.1	Gene:	Mpp7 / 75739	MGIID:	1922989	Length:	601	Species:	Mus musculus

Alignment Length:	604	Identity:	199/604 - (32%)
Similarity:	318/604 - (52%)	Gaps:	100/604 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 DAHVDADVLRDMLRDNRLHQFLQLFDRIAA-----TVVTSNGRAPAAEAVGRCRDVLEQLSSTSG 421
            |:..|...|.|:..:..||..:::.:::..     .:...:|.|..|:      |:.|:|.:...
Mouse    30 DSQEDLTFLWDVFGEKSLHSLVKIHEKLHCYEKQNPLPILHGAAALAD------DLTEELQNKLP 88

  Fly   422 GNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGE 486
            .:.:      .||::||:.|:::|||..||.||:..|..    |.||  ||    |::|:.|..
Mouse    89 NSEI------RELLKLLSKPNVKALLSVHDTVAQKSYDP----VLPP--VP----DDIDDEEDS- 136

  Fly   487 LQHVTRVRLVQFQKNTDEPMGITLKMTED-GRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQ 550
                  |::::..||: ||:|.|:|..|. |...|||||.||...|...:|||||:||:||.||:
Mouse   137 ------VKIIRLVKNS-EPLGATIKKDEQTGAITVARIMRGGAADRSGLIHVGDELREVNGIPVE 194

  Fly   551 HQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE--IFVRAQFDYNPLDDELIPCAQAGISFQVG 613
            .:...::.::|.:::|::||||:||.:...|..|  ||::|.|||:|.:|:.|||.:||:||:.|
Mouse   195 DKRPEEIIKILSQSKGAITFKIIPSTKEETPSKEGKIFIKALFDYDPKEDKAIPCKEAGLSFRKG 259

  Fly   614 DILQIISKDDHHWWQARLD-TVGGSAGLIPSPELQEWRIACQTVD-----------KTKQEQVNC 666
            |||||:|:||..||||:.: .....||||||...||.|:|.:..:           |:.:|.|.|
Mouse   260 DILQIMSQDDVTWWQAKHEGDANPRAGLIPSKHFQERRLALRRPEIVVQPLKLSNTKSYEETVEC 324

  Fly   667 S----------------IFG---------RKKKQCRDKYLAKHNAIFDTLDVVTYEEVV--KVPV 704
            .                |.|         :.||..:..|..|.:..:||.||.|||||.  :..:
Mouse   325 EEIKEDTGHDGNNSGTYIAGFRRSFRLSRKNKKINKSMYECKKSEQYDTADVPTYEEVTPYRRQI 389

  Fly   705 GDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMM 769
            .|   :.:.:||:|..|||...:|..|:......|...:|||||..:.:|.:|..|.|:|.....
Mouse   390 HD---KYRLIVLVGPVGVGLNELKRKLLMSDAQHYGVIVPHTTRARRSQESDGVEYIFISKHLFE 451

  Fly   770 ADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSL 834
            .|:..|:::|||.:::..|||.:|::|.:..:.|:.:|||:|..:|.|||.||.|||:||..||:
Mouse   452 TDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSI 516

  Fly   835 QNI------------ADYDGS--------LERLAKESEMLRQLYGHFFDLTIVNNDISETIATLE 879
            :.:            .|..|:        .:.:.|.::::...|||.||..|:|:|::.....|:
Mouse   517 ERLRETRKNAKIISSRDDQGTAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELK 581

  Fly   880 TAIDRVHTTPQWVPVSWLY 898
            |..|::.|...|||||||:
Mouse   582 TTFDKLETDTHWVPVSWLH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	6/38 (16%)
		L27	406..462	CDD:280918	16/55 (29%)
		PDZ_signaling	493..573	CDD:238492	34/80 (43%)
		SH3_CASK	586..646	CDD:213014	33/60 (55%)
		Guanylate_kin	710..883	CDD:279019	60/192 (31%)
		GuKc	720..883	CDD:214504	57/182 (31%)
Mpp7	XP_011245327.1	L27	16..68	CDD:197794	6/37 (16%)
		L27	75..125	CDD:197794	18/65 (28%)
		PDZ_signaling	137..217	CDD:238492	34/80 (43%)
		SH3_MPP7	232..292	CDD:212966	33/59 (56%)
		GuKc	403..588	CDD:214504	58/184 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810