DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and Dlg5

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_017171686.1 Gene:Dlg5 / 71228 MGIID:1918478 Length:1931 Species:Mus musculus


Alignment Length:775 Identity:144/775 - (18%)
Similarity:235/775 - (30%) Gaps:281/775 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   369 VLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGR---------CRDVLEQLSSTSGGNS 424
            :||:.:...|.|:.|............|...:|:.:..||         |.|..| :.::.|.||
Mouse  1201 ILRNPIYTVRSHRVLPCGSPPVPRDAGSQSLSPSVQHQGRLSLDLSHRACSDYSE-MRASQGSNS 1264

  Fly   425 L---------GGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELD 480
            |         .....|.|.:::...|.     :...|:..|.........:.||..| ||.|.|.
Mouse  1265 LPSSARLGSSSNLQFKAERIKIPLTPR-----YPRSVMGSDRGSLSHSECSTPPRSP-LNIDTLS 1323

  Fly   481 NV------------------EGGELQ----HVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARI 523
            :.                  ..||.:    .|...|.|:.||.: ||:||::...|.|...|:::
Mouse  1324 SCSQPQTTASTLPRIAVNPSSHGERRKDRPFVEEPRHVKVQKGS-EPLGISIVSGEKGGVYVSKV 1387

  Fly   524 MHGGMIHRQATLHVGDEIREING----------------------------QPVQHQ-------- 552
            ..|.:.| ||.|..||::.|.||                            .|..||        
Mouse  1388 TLGSIAH-QAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHIHQLNSHSRSS 1451

  Fly   553 ----------------SVGQ------LQRMLREARG----------SVTFKIVPSYRSAPPPCEI 585
                            |.|.      :..::.:..|          |.|..:..:.:..|.|..:
Mouse  1452 SHLDPAATPHSTLQGSSAGTPEHPSVIDPLMEQDEGPGTPPAKQSASSTRSVGDTTKKTPDPRIV 1516

  Fly   586 FV-RAQFD--------------------------------------YNPLD-------------- 597
            |: ::|.|                                      |..||              
Mouse  1517 FIKKSQLDLGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDMRSRTVEDVYVEML 1581

  Fly   598 ---DEL------------------------------IPCAQAGISFQVGDILQIISKDD------ 623
               |.|                              :...:..:||:..|||.:   ||      
Mouse  1582 KPKDSLRLKVQYRHEEFTRVKGLPGDSFYIRALYDRLAEVEPELSFKKDDILYV---DDTLPQGV 1643

  Fly   624 -HHW--WQARLDTVGGSAGLIPSPEL--QEW--RIACQTVD-----KTKQEQVNCSIFGRKKKQC 676
             ..|  ||...:......|.|||..:  ||:  |::...|.     ||.......|.|.||.|..
Mouse  1644 FGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNTAKTLSAAARRSFFRRKHKHK 1708

  Fly   677 R------------DKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKN 729
            |            |.:......:|:....:.|:.|.||   |....|..|:|    |.....:|.
Mouse  1709 RSGSKDGKDLLALDTFSNDSIPLFEDSVSLAYQRVQKV---DCTSLRPVLLL----GPLLDVVKE 1766

  Fly   730 TLISKYPDKYA-YPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLD 793
            .|:::.|.|:. .|:.......:..|...:...||            :|.....|.|.   |.:.
Mouse  1767 MLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFV------------DYKRRSGHFDV---TTVA 1816

  Fly   794 TIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY-------DGSLERLAKE- 850
            :|:.|..:.:..:||:.|.|::.|......|.|:||...|.::|.:.       |...:|.:|| 
Mouse  1817 SIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSKEQ 1881

  Fly   851 ---SEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLYXQDSELECP 907
               ::.:.|.|..:|...:....:|.....:...:.:..:...|:|.           ||
Mouse  1882 FETAQKIDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIPA-----------CP 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996
S_TKc 12..278 CDD:214567
L27 347..396 CDD:280918 5/26 (19%)
L27 406..462 CDD:280918 14/73 (19%)
PDZ_signaling 493..573 CDD:238492 29/147 (20%)
SH3_CASK 586..646 CDD:213014 22/154 (14%)
Guanylate_kin 710..883 CDD:279019 37/184 (20%)
GuKc 720..883 CDD:214504 34/174 (20%)
Dlg5XP_017171686.1 Takusan 129..213 CDD:368141
Smc <141..564 CDD:224117
PDZ_signaling 625..712 CDD:238492
PDZ_signaling <741..800 CDD:238492
PDZ 1357..1439 CDD:214570 21/83 (25%)
dbPDZ_assoc 1437..1512 CDD:374667 8/74 (11%)
PDZ 1513..1594 CDD:214570 9/80 (11%)
SH3_DLG5 1610..1672 CDD:212794 14/64 (22%)
GuKc 1744..1920 CDD:214504 40/197 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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