DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	356	Identity:	79/356 - (22%)
Similarity:	130/356 - (36%)	Gaps:	85/356 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 NSLGGKYAKE-----ELMRLLAAPHMQALLHSHDVVARDVYGEEA-LRV--TPPPM--------- 470
            :.||..:|.|     ..::.:|.||::          |.....|| |||  |..|:
Mouse   256 SELGNGHAFELENGPNSLKDVAGPHLE----------RSEADREAELRVPKTEAPLSDSNDKRRF 310

  Fly   471 -----VPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGR--------CIVAR 522
                 ..:.:.|.|...|.|      |:..::..|.:|   |:.:::: .||        .:|.:
Mouse   311 SKTGKTNFQSSDSLAREEVG------RIWKMELLKESD---GLGIQVS-GGRGSKRSPHAIVVTQ 365

  Fly   523 IMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFV 587
            :..||..||...|.:|||:..|||..:...|..:...:||.|.|.|...:.....||.
Mouse   366 VKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKESSAE------- 423

  Fly   588 RAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVG-GSAG----LIPSPELQ 647
                |...|..:.:|    .::..|.||......:|..  .||.|..| |||.    ::.|.|.|
Mouse   424 ----DLLKLTSKSLP----DLTSSVEDISSWTDNEDQE--AARDDEEGTGSAAVRGTMLGSEESQ 478

  Fly   648 EWRIACQTVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRK 712
            :    ..:.:::|...:.....|..|.:.:.:.   ...:.....|..|.|:: |..|||..:
Mouse   479 D----VGSSEESKGNNLESPKQGNSKMKLKSRL---SGGVHRLESVEEYNELM-VRNGDPRIR-- 533

  Fly   713 TLVLLGAHGVGRRHIKNTLISKYPDKYAYPI 743
               :|.....||:|....|:........|.|
Mouse   534 ---MLEVSRDGRKHSLPQLLDSTGTSQEYHI 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918	8/43 (19%)
		PDZ_signaling	493..573	CDD:238492	23/87 (26%)
		SH3_CASK	586..646	CDD:213014	15/64 (23%)
		Guanylate_kin	710..883	CDD:279019	7/34 (21%)
		GuKc	720..883	CDD:214504	6/24 (25%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492	23/84 (27%)
		PDZ_signaling	591..672	CDD:238492
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900