DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Dlg2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_038945240.1	Gene:	Dlg2 / 64053	RGDID:	619895	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	184/749 - (24%)
Similarity:	299/749 - (39%)	Gaps:	192/749 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAG-IEAVQ 348
            :|..:.:||.|:|.:...   ||...:||||.....: ..|..:.:|...|..|.::.| ::...
  Rat   325 RRRPILETVVEIKLFKGP---KGLGFSIAGGVGNQHI-PGDNSIYVTKIIDGGAAQKDGRLQVGD 385

  Fly   349 RILDCLDDIYSLQD-AHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDV 412
            |:|  :.:.|||:: .|.:|..:   |::.....:|::..  ..|:..::...|.        |:
  Rat   386 RLL--MVNNYSLEEVTHEEAVAI---LKNTSDVVYLKVGK--PTTIYMTDPYGPP--------DI 435

  Fly   413 LEQLSSTSGGNSLGGKYAKEELMRLL--AAPHMQALLHSHDVVARD-------VYG--------- 459
            ....|.....:.|.|.....|....|  .:|...:.:..|.:|..|       ||.
  Rat   436 THSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKP 500

  Fly   460 ------------EEALRVTPPP-----MVPYLNGDELDNVEGGELQHVTRVR--LVQFQKNTD-- 503
                        :..|..||.|     ::|       |:......||.|..|  .|..|:...
  Rat   501 ASPRHYSPVECDKSFLLSTPYPHYHLGLLP-------DSDMTSHSQHSTATRQPSVTLQRAISLE 558

  Fly   504 -EP-----------MGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVG 555
             ||           :|..:...|||..| |:.|:.||.......|..||:|..:||..::..|..
  Rat   559 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 623

  Fly   556 QLQRMLREARGSVTFKIVPSY------------------------------------RSAPPPCE 584
            |....|:.|..:||  |:..|                                    ||
  Rat   624 QAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS------ 680

  Fly   585 IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQAR---LDTVGGSAGLIPSP-- 644
            ::|||.|||:...|..:|  ..|:||:.||||.:|:..|..|||||   ||......|:|||.
  Rat   681 LYVRAMFDYDKSKDSGLP--SQGLSFKYGDILHVINASDDEWWQARRVILDGDSEEMGVIPSKRR 743

  Fly   645 -ELQEWRIACQTV----------------DKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLD 692
             |.:| |...:||                ||.|:.    .||.||....::|..::.    :|.|
  Rat   744 VERKE-RARLKTVKFNAKPGVIDSKGSFNDKRKKS----FIFSRKFPFYKNKEQSEQ----ETSD 799

  Fly   693 ----------------------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKY 735
                                  :::||.|.:..:   |:.|..::|    |..:..|.:.|||::
  Rat   800 PEQHVSSNASDSESSCRGQEDLILSYEPVTRQEI---NYTRPVIIL----GPMKDRINDDLISEF 857

  Fly   736 PDKYAYPIPHTTRPAKPEEENGRSYYFV-SHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIH 799
            |||:...:||||||.:..|.:||.|:|| |.::|..||..::::|.|.:.|.:|||.:.::|.:.
  Rat   858 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA 922

  Fly   800 TEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSL-ERLAKESE----MLRQLYG 859
            ..||..||||...|:|.|:.|:..|..:||...||:.:.:.:..| |..||::.    .|.|.:|
  Rat   923 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFG 987

  Fly   860 HFFDLTIVNNDISETIATLETAIDRVHTTPQWVP 893
            .:|...:..:.:.:.....:..|:.......|:|
  Rat   988 EYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	6/22 (27%)
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	10/49 (20%)
		L27	406..462	CDD:280918	12/85 (14%)
		PDZ_signaling	493..573	CDD:238492	26/96 (27%)
		SH3_CASK	586..646	CDD:213014	28/65 (43%)
		Guanylate_kin	710..883	CDD:279019	56/178 (31%)
		GuKc	720..883	CDD:214504	54/168 (32%)
Dlg2	XP_038945240.1	L27_1	2..62	CDD:401120
		MAGUK_N_PEST	157..239	CDD:402306
		PDZ_signaling	240..324	CDD:238492
		PDZ_signaling	333..418	CDD:238492	23/93 (25%)
		PDZ_assoc	420..487	CDD:402299	12/76 (16%)
		PDZ_signaling	561..639	CDD:238492	22/79 (28%)
		SH3_DLG2	676..749	CDD:212965	32/81 (40%)
		Guanylate_kin	835..1013	CDD:395500	57/181 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810