DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and Dlg3

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_006257142.1	Gene:	Dlg3 / 58948	RGDID:	68423	Length:	867	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	211/874 - (24%)
Similarity:	340/874 - (38%)	Gaps:	190/874 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 NSAPVKLGGFGS--------AIQLPGTRETIETHGR-VG-CPHYMAPEVVTRRLYGKGCDVWGAG 208
            |.|....||:.|        |...|.|:..:...|| || .|....|...|.:|.|.|...|
  Rat    45 NGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSGPSWW--- 106

  Fly   209 VMLHVLLSGRLPFLGSGVR---LQQSVARGRLSFEAPEWKSISANAKDLVMK-----MLAANPHH 265
                       |......|   .|.|.|...::.||.| .|:|.|..|.:.|     :...|...
  Rat   107 -----------PECTCTNRDWYEQASPAPLLVNPEALE-PSLSVNGSDGMFKYEEIVLERGNSGL 159

  Fly   266 RLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAG--GTNMDPLYATDADM 328
            ..||...:|:|.:.|...:..|.:               :.|...|:.|  |.|...|...:.|:
  Rat   160 GFSIAGGIDNPHVPDDPGIFITKI---------------IPGGAAAMDGRLGVNDCVLRVNEVDV 209

  Fly   329 -PITGATDEWADEEAGIEAVQRIL--------DCLDDIYSLQ--------------DAHVDAD-- 368
             .:..:....|.:|||  .|.|::        :.:.::..|:              :.|:..|
  Rat   210 SEVVHSRAVEALKEAG--PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS 272

  Fly   369 -VLRDML------RDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCR---DVLEQLSSTSGGN 423
             .:..::      :|.|    ||:.||:.|...|:.......|||...:   |::....:..|..
  Rat   273 IYITKIIEGGAAQKDGR----LQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSL 333

  Fly   424 SLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVT--PPPMVPYLNGDELDNVEGGE 486
            .|...||..:......|.....:.|:..:   ...|....:||  .||.||......:......|
  Rat   334 HLNDMYAPPDYASTFTALADNHISHNSSL---GYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAE 395

  Fly   487 LQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCI-VARIMHGGMIHRQATLHVGDEIREINGQPVQ 550
            .......|.:...|.: ..:|..:...|||..| |:.|:.||.......|..||.|..:||..::
  Rat   396 EDFTREPRKIILHKGS-TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 459

  Fly   551 HQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE------------------------------- 584
            :.:..|....|:.|..|||  ||..||    |.|
  Rat   460 NATHEQAAAALKRAGQSVT--IVAQYR----PEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSE 518

  Fly   585 ---IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSA---GLIPS 643
               ::|||.|||:...|..:|  ..|:||..||||.:|:..|..||||||.|..|.:   |:|||
  Rat   519 KRSLYVRALFDYDRTRDSCLP--SQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPS 581

  Fly   644 PELQE--WRIACQTVD---KTKQEQVNCSIFGRKKKQCR----------------DKYLAKHNAI 687
            .:..|  .|...:||.   :|...:.|.||..::||..|                :|.:.:....
  Rat   582 KKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQEKSIQEQGVT 646

  Fly   688 FDTLD-----------VVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAY 741
            .:|.|           :::||.|.:..:   ::.|..::|    |..:..:.:.|||::|.|:..
  Rat   647 SNTSDSESSSKGQEDAILSYEPVTRQEI---HYARPVIIL----GPMKDRVNDDLISEFPHKFGS 704

  Fly   742 PIPHTTRPAKPEEENGRSYYF-VSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMA 805
            .:||||||.:..|.:|:.|:| ||.::|..||..|:::|.|...|.:|||.:.::|.:...||..
  Rat   705 CVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHC 769

  Fly   806 ILDVEPQALKILRTAEFTPYVVFIAAPSLQNIAD------YDGSLERLAKESEMLRQLYGHFFDL 864
            ||||...|:|.|:.|:..|..:||...|::.:.:      |: ...::..::..|.|.:|.:|..
  Rat   770 ILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYE-QANKIFDKAMKLEQEFGEYFTA 833

  Fly   865 TIVNNDISETIATLETAIDRVHTTPQWVP 893
            .:..:.:.|....::..|:.......|||
  Rat   834 IVQGDSLEEIYNKIKQIIEDQSGHYIWVP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	39/171 (23%)
		S_TKc	12..278	CDD:214567	37/141 (26%)
		L27	347..396	CDD:280918	12/79 (15%)
		L27	406..462	CDD:280918	9/58 (16%)
		PDZ_signaling	493..573	CDD:238492	23/80 (29%)
		SH3_CASK	586..646	CDD:213014	29/62 (47%)
		Guanylate_kin	710..883	CDD:279019	51/179 (28%)
		GuKc	720..883	CDD:214504	49/169 (29%)
Dlg3	XP_006257142.1	MAGUK_N_PEST	52..148	CDD:287565	30/110 (27%)
		PDZ_signaling	149..226	CDD:238492	18/93 (19%)
		PDZ_signaling	242..328	CDD:238492	15/89 (17%)
		PDZ_assoc	329..403	CDD:287558	14/76 (18%)
		PDZ_signaling	402..480	CDD:238492	23/80 (29%)
		SH3_DLG3	520..586	CDD:212962	29/67 (43%)
		Guanylate_kin	676..854	CDD:279019	52/182 (29%)
		GuKc	687..854	CDD:214504	49/167 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810