DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Mpp4

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_038940071.1	Gene:	Mpp4 / 58808	RGDID:	620016	Length:	636	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	200/640 - (31%)
Similarity:	315/640 - (49%)	Gaps:	88/640 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 QAIAGGTNMDPLYA--TDADMPITGATDEWADEEAGIEAVQRILDCLDDI---YSLQDAHVDADV 369
            ||.||........|  ||.|..::.|    .:.|.|:..:.|:|  |.::   || :|.| ...:
  Rat    27 QAPAGRMRQSDRGAELTDEDRALSTA----PNPENGLSGILRLL--LQELSLFYS-RDVH-GLCL 83

  Fly   370 LRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEEL 434
            |.|:|....|...|:::|.:..........|.....:..| :|||.|...|....:      :||
  Rat    84 LYDLLHSPWLQALLKVYDCLQKFKEKKLVPATTHAQILSC-EVLELLPKASSSPEI------QEL 141

  Fly   435 MRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQ 499
            .::|.|||.:|||.:||.||:..:         .|::|.|.    ||:...|    ..:|.|...
  Rat   142 RQVLQAPHCKALLRAHDTVAQKDF---------EPLLPPLP----DNIPDSE----EAMRTVCLV 189

  Fly   500 KNTDEPMGITLKMTE-DGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLRE 563
            || .:|:|.|:|..| .|..:|||::|||::.|...|:.||::.|:||.||:.....|:..:|..
  Rat   190 KN-QQPLGATIKRHEITGDILVARVIHGGLVERSGLLYAGDKLVEVNGVPVEGLDPEQVIHILAM 253

  Fly   564 ARGSVTFKIVPSYRSAPP---PCEIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHH 625
            :.|::.||::|.  ||||   ...::|||..||.|.:|..|||..||:.|..||||||:.:.|..
  Rat   254 SCGTIMFKVIPV--SAPPVSSQTTVYVRAMIDYWPQEDPDIPCMDAGLPFLKGDILQIVDQSDAL 316

  Fly   626 WWQAR-LDTVGGSAGLIPSPELQE-------WR-----IACQTVDKTKQE------QVNCSIFGR 671
            ||||| :..:...||||||..|.:       |.     ..|....::|:|      |...:.|.|
  Rat   317 WWQARKISDLAICAGLIPSNHLLKRKQREFWWSQPYQPHTCLKSTRSKEEFVGDGQQFFIAGFRR 381

  Fly   672 KKKQCRDK--YLAKHNAIFDTLDVVT-----YEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKN 729
            ..:.||.|  :...|..:..|....:     |||||:.. ..|..:.:.:||:|..|||...::.
  Rat   382 SMRLCRRKSHFSQLHANMRCTCSCYSAVGAPYEEVVRYQ-RQPADKHRLIVLVGPSGVGVNELRR 445

  Fly   730 TLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDT 794
            .||...|..:...:|||||..|..|.:||.|::||.:...:.:..:..||:|.::..:|||.::.
  Rat   446 QLIGCNPSCFQSAVPHTTRSPKSYEMDGREYHYVSRETFESLMYGHRMLEFGEYKGHLYGTSVNA 510

  Fly   795 IRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQN----------IADY-------DG 842
            :..:..|||:.::|:|||.:::.||.|..|||:||..||:.:          |.||       |.
  Rat   511 VLAVLDEGKICVMDLEPQDIQLARTRELKPYVIFIKPPSMSSMRHSRRNAKIITDYFVDMKFKDE 575

  Fly   843 SLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897
            .|:.:.:.::.:...:|.|||..|||:::.:..|.|.:||.:.....||||.:|:
  Rat   576 DLQEMEELAQKMESQFGQFFDHVIVNDNLQDARAQLLSAIQKAEEELQWVPEAWV 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	13/51 (25%)
		L27	406..462	CDD:280918	19/55 (35%)
		PDZ_signaling	493..573	CDD:238492	30/80 (38%)
		SH3_CASK	586..646	CDD:213014	31/60 (52%)
		Guanylate_kin	710..883	CDD:279019	59/189 (31%)
		GuKc	720..883	CDD:214504	56/179 (31%)
Mpp4	XP_038940071.1	L27	<79..114	CDD:197794	7/35 (20%)
		L27	124..171	CDD:197794	19/61 (31%)
		PDZ_signaling	184..263	CDD:238492	30/79 (38%)
		SH3_MPP4	277..337	CDD:212967	31/59 (53%)
		Guanylate_kin	428..618	CDD:395500	60/189 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810