DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and MPP4

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_149055.2 Gene:MPP4 / 58538 HGNCID:13680 Length:637 Species:Homo sapiens


Alignment Length:666 Identity:195/666 - (29%)
Similarity:317/666 - (47%) Gaps:134/666 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 DMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVD-ADVLRDMLRDNRLHQFLQLFD--- 387
            ||.::.||    :.:.|:..:.|::  |.::.......|: ..:|.|:|....|...|:::|   
Human    15 DMKLSTAT----NPQNGLSQILRLV--LQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQ 73

  Fly   388 ------RIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQAL 446
                  .:.||        |.|:.:.  .:|:|.|..|.....:      :||.::|.|||.:||
Human    74 EFKEKKLVPAT--------PHAQVLS--YEVVELLRETPTSPEI------QELRQMLQAPHFKAL 122

  Fly   447 LHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLK 511
            |.:||.:|:..:         .|::|.|.    ||:...|    ..:|:|...|| .:|:|.|:|
Human   123 LSAHDTIAQKDF---------EPLLPPLP----DNIPESE----EAMRIVCLVKN-QQPLGATIK 169

  Fly   512 MTE-DGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPS 575
            ..| .|..:||||:|||:..|...|:.||::.|:||..|:.....|:..:|..:||::.||:|| 
Human   170 RHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVP- 233

  Fly   576 YRSAPPPCE----IFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQAR-LDTVG 635
              .:.||..    ::|||..:|.|.:|..|||..||:.||.||||||:.::|..||||| :....
Human   234 --VSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPA 296

  Fly   636 GSAGLIPSPELQE-------WRIACQ-------TVDKTKQEQVNCSI------------------ 668
            ..|||:||..|.:       |....|       |:..:.:|:.:..|                  
Human   297 TCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELS 361

  Fly   669 -----------------FGRKKKQCRDK-YLAK-HNAIFDTLDVVT-----YEEVVKVPVGDPNF 709
                             |.|..:.||.| :|:. |.::..|....:     |||||:.. ..|:.
Human   362 EDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ-RRPSD 425

  Fly   710 QRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGA 774
            :.:.:||:|..|||...::..||...|..:...:|||||..|..|.|||.|::||.:.....|.:
Human   426 KYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYS 490

  Fly   775 NEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSL----- 834
            :..||||.::..:|||.:|.::.:..|||:.::|:|||.::.:||.|..|||:||...::     
Human   491 HRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQ 555

  Fly   835 -----QNIADY-------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHT 887
                 :.|.||       |..|:.:...::.:...:|.|||..|||:.:.:..|.|.:||.:...
Human   556 SRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQE 620

  Fly   888 TPQWVPVSWLYXQDSE 903
            .|||||.:|:  .|:|
Human   621 EPQWVPATWI-SSDTE 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996
S_TKc 12..278 CDD:214567
L27 347..396 CDD:280918 11/58 (19%)
L27 406..462 CDD:280918 16/55 (29%)
PDZ_signaling 493..573 CDD:238492 31/80 (39%)
SH3_CASK 586..646 CDD:213014 30/60 (50%)
Guanylate_kin 710..883 CDD:279019 61/189 (32%)
GuKc 720..883 CDD:214504 58/179 (32%)
MPP4NP_149055.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 2/6 (33%)
L27 30..83 CDD:197794 9/54 (17%)
L27 90..140 CDD:197794 17/66 (26%)
PDZ_signaling 153..232 CDD:238492 31/79 (39%)
SH3_MPP4 246..306 CDD:212967 30/59 (51%)
Guanylate_kin 428..618 CDD:331880 62/189 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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