DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and Pals2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001158205.1	Gene:	Pals2 / 56524	MGIID:	1927340	Length:	553	Species:	Mus musculus

Alignment Length:	589	Identity:	227/589 - (38%)
Similarity:	337/589 - (57%)	Gaps:	73/589 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 VQRILDCLDDIYSLQDA-HVDADVLRDMLRDNRLHQFLQLFDRIAAT---VVTSNGRAPAAEAVG 407
            :|::|:.|.::.|...| .:|...|:.::.:..:....:..:|:..:   .|:.|.    .|.|
Mouse     1 MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNN----LELV- 60

  Fly   408 RCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVP 472
              .::||.::...   |:....|  ||:.:|..||.|:||.:||:||...|..       ||..|
Mouse    61 --NEILEDITPLI---SVDENVA--ELVGILKEPHFQSLLEAHDIVASKCYDS-------PPSSP 111

  Fly   473 YLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHV 537
            .:|...|:|    :|. |..:|::...|...||:|:|.:: |:...::|||:|||||.||..|||
Mouse   112 EMNIPSLNN----QLP-VDAIRILGIHKKAGEPLGVTFRV-ENNDLVIARILHGGMIDRQGLLHV 170

  Fly   538 GDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPP--------------CEIFVR 588
            ||.|:|:||..|.: :..:||.:|:...||||.||:||||....|              .::||:
Mouse   171 GDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKILPSYRDTITPQQSYVNMERHPAHVRQVFVK 234

  Fly   589 AQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIAC 653
            ..|||||.:|.||||.:||:.|..|:||||::::|.:||||.....|||||||||..|:|.|.|.
Mouse   235 CHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAF 299

  Fly   654 QTVDKTKQEQVN----CSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTL 714
                 .:::..|    |.....|||: :..||...||.||..::..||||.|:    |.||||||
Mouse   300 -----VRRDWDNSGPFCGTISNKKKK-KMMYLTTRNAEFDRHEIQIYEEVAKM----PPFQRKTL 354

  Fly   715 VLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLE 779
            ||:||.|||||.:||..|...|.::...:|.|:|..:.:|::|::|.|||..||.|||.|.:|||
Mouse   355 VLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLE 419

  Fly   780 YGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY---- 840
            :|.:|..:||||:|:|..:...|:..||||.|||||:|||:||.|||||||||.|:.:...
Mouse   420 HGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAV 484

  Fly   841 -----------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPV 894
                       |..|::...||..:::.|.|:|||.|||:::.:....|:|||:::...|||||:
Mouse   485 VDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFEKLQTAIEKLRMEPQWVPI 549

  Fly   895 SWLY 898
            ||:|
Mouse   550 SWVY 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	9/52 (17%)
		L27	406..462	CDD:280918	18/55 (33%)
		PDZ_signaling	493..573	CDD:238492	35/79 (44%)
		SH3_CASK	586..646	CDD:213014	34/59 (58%)
		Guanylate_kin	710..883	CDD:279019	84/187 (45%)
		GuKc	720..883	CDD:214504	75/177 (42%)
Pals2	NP_001158205.1	L27	2..55	CDD:197794	9/52 (17%)
		L27	57..108	CDD:397114	19/65 (29%)
		PDZ_signaling	132..205	CDD:238492	34/74 (46%)
		SH3_MPP6	232..292	CDD:212971	34/59 (58%)
		Guanylate_kin	350..540	CDD:395500	85/189 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740