DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CASK and Pals1

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:NP_062525.1 Gene:Pals1 / 56217 MGIID:1927339 Length:675 Species:Mus musculus


Alignment Length:716 Identity:221/716 - (30%)
Similarity:370/716 - (51%) Gaps:94/716 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 SVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPW--------IRDRDKLQRT 287
            |...|.::.|:      .:..|:|.:......|.||   ...:|.|.        :|...:|:| 
Mouse     4 SYMNGHVTEES------DSGIKNLDLASPEEYPKHR---EMAVDCPGDLGTRMMPVRRSAQLER- 58

  Fly   288 HLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATDEWADEEAGI-----EAV 347
             :....|:::|   ||:.:|..|.:...::| .|.......|.||..:...|.|.||     ...
Mouse    59 -IRQQQEDMRR---RREEEGKKQELDLNSSM-RLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYA 118

  Fly   348 QRILDCLDDIYS----LQDAHVDADVLRDM-----LRDNRLHQFLQLFDRIAATVVTSNGRAPAA 403
            ..||| ::|::|    :|...||:....|:     |..||  .|...|....|..|..:..:|..
Mouse   119 VNILD-VEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNR--DFQNAFKIHNAVTVHMSKASPPF 180

  Fly   404 EAVGRCRDVLEQLSSTSGGNSLGGKYAKE--ELMRLLAAPHMQALLHSHDVVARDVYGEEALRVT 466
            ..:...:|:::::.:.     |...:.||  ||..||.|||:||||.:||.||     |:.:::.
Mouse   181 PLIANVQDLVQEVQTV-----LKPVHQKEGQELTALLNAPHIQALLLAHDKVA-----EQEMQLE 235

  Fly   467 PPPMVPYLNGDE--LDNV--EGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGG 527
            |..       ||  .:::  .|||     .|::|:.:|..|.|:|.|::...|. .|::||:.||
Mouse   236 PIT-------DERVYESIGHYGGE-----TVKIVRIEKARDIPLGATVRNEMDS-VIISRIVKGG 287

  Fly   528 MIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCE---IFVRA 589
            ...:...||.|||:.||||..::.:.|.::..:|.:..|::||.::||.:..|||.:   |.|:|
Mouse   288 AAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKA 352

  Fly   590 QFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGS-----AGLIPSPELQEW 649
            .|||:|.||..:||.:.|:|||.||||.:||::|.:||||..:  |..     |||:|....|:.
Mouse   353 HFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYRE--GDEDNQPLAGLVPGKSFQQQ 415

  Fly   650 RIAC-QTVDKTKQEQVNCSIF-GRKKKQCRDK--YLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQ 710
            |.|. ||:::.|:.:.:..:: .:|.|:.|.|  |.|..|..:|..:::||||:..  ...|..:
Mouse   416 REAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSL--YHQPANR 478

  Fly   711 RKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGAN 775
            ::.::|:|....|:..::..|::|..|::|..:|||||..:..|..||.|:|||.....|||.|.
Mouse   479 KRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAG 543

  Fly   776 EYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPS---LQNI 837
            :::|:|..|..:|||.:|::|::...||:.:|.:..|:||.||.::..||::|||.||   |:.:
Mouse   544 KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRAL 608

  Fly   838 ADYDG------SLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSW 896
            ...:|      .|..:.:::..:.|..||:||..|||:|:.:....|...|:::.|.|||||.:|
Mouse   609 LAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTW 673

  Fly   897 L 897
            |
Mouse   674 L 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 17/84 (20%)
S_TKc 12..278 CDD:214567 10/54 (19%)
L27 347..396 CDD:280918 16/57 (28%)
L27 406..462 CDD:280918 20/57 (35%)
PDZ_signaling 493..573 CDD:238492 27/79 (34%)
SH3_CASK 586..646 CDD:213014 30/64 (47%)
Guanylate_kin 710..883 CDD:279019 59/181 (33%)
GuKc 720..883 CDD:214504 57/171 (33%)
Pals1NP_062525.1 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000269|PubMed:17182851 1..345 103/381 (27%)
Interaction with PARD6B. /evidence=ECO:0000269|PubMed:15140881 21..140 30/128 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..79 9/32 (28%)
L27_N 123..170 CDD:370269 13/49 (27%)
Interaction with LIN7C. /evidence=ECO:0000269|PubMed:10753959 181..243 23/78 (29%)
L27 189..237 CDD:197794 19/57 (33%)
PDZ_signaling 254..333 CDD:238492 27/79 (34%)
SH3_MPP5 349..411 CDD:212969 30/63 (48%)
GuKc 491..661 CDD:214504 58/169 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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