DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and cask

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_012812392.1	Gene:	cask / 548958	XenbaseID:	XB-GENE-1014725	Length:	926	Species:	Xenopus tropicalis

Alignment Length:	947	Identity:	575/947 - (60%)
Similarity:	708/947 - (74%)	Gaps:	70/947 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATI 65
            |.:|::||:|||||||||||||||:|||||:||:.||||||||||||||:||||||.||||||:|
Frog     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASI 65

  Fly    66 CHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALR 130
            ||||||||||||||||||:||||||||||:|:|||||:|:||.||||||||||.|||||||||||
Frog    66 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 130

  Fly   131 YCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTR 195
            |||:|:|:||||:|.|.|||:.:|||||||||||.||||  ....:...||||.||:||||||.|
Frog   131 YCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVKR 193

  Fly   196 RLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLA 260
            ..|||..||||.||:|.:||||.|||.|:..||.:.:.:|:......:|..||.:|||||.:||.
Frog   194 EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWNHISESAKDLVRRMLM 258

  Fly   261 ANPHHRLSITEVLDHPWIRDRDK-LQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYAT 324
            .:|..|:::.|.|:|||:::||: ..:.||.:|||:|:::||||||||||.|.......:..|
Frog   259 LDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFY-- 321

  Fly   325 DADMPITGATDEWAD--EE-------AGIEAVQRILDCLDDIYSLQD-AHVDADVLRDMLRDNRL 379
             .|.|     :|..|  |:       |...||.::||.|::|::|.| :..|.|.|..:.:|..|
Frog   322 -GDPP-----EELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHL 380

  Fly   380 HQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQ 444
            |..|.|:|:| .|..:...|.|.::||.|.::|||::|.....|.      .:||.|:|..||..
Frog   381 HTLLDLYDKI-NTKSSPQIRNPPSDAVQRAKEVLEEISCYPENND------AKELKRILTQPHFM 438

  Fly   445 ALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG-ELQHVTRVRLVQFQKNTDEPMGI 508
            |||.:|||||.:||.:|||||||||..||||||..::..|. ::::|||||||||||||||||||
Frog   439 ALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGI 503

  Fly   509 TLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIV 573
            ||||.|...|||||||||||||||.|||||||||||||..|.:|:|.|||:||||.|||:|||||
Frog   504 TLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIV 568

  Fly   574 PSYRSAPPPCE-----------------------------------IFVRAQFDYNPLDDELIPC 603
            ||||:....||                                   |:|||||:|:|..|:||||
Frog   569 PSYRTQSSSCERDSPSTSRQSPANGHSSINNSVSDIPTTTQTKGRQIYVRAQFEYDPAKDDLIPC 633

  Fly   604 AQAGISFQVGDILQIISKDDHHWWQARLDTV-GGSAGLIPSPELQEWRIACQTVDKTKQE-QVNC 666
            .:|||.|:||||:||||||||:|||.:|:.. .|:|||||||||||||:||..::||||| |.:|
Frog   634 KEAGIRFRVGDIIQIISKDDHNWWQGKLENAKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASC 698

  Fly   667 SIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTL 731
            :.||:||||.:|||||||||:||.||:||||||||:|.    |:|||||||||||||||||||||
Frog   699 TWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPA----FKRKTLVLLGAHGVGRRHIKNTL 759

  Fly   732 ISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIR 796
            |:|:||::||||||||||.|.:||||::|:|||||:||.||..|||||||:||||||||||:|||
Frog   760 ITKHPDRFAYPIPHTTRPPKKDEENGKNYFFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIR 824

  Fly   797 RIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLERLAKESEMLRQLYGHF 861
            :||.:|.:|||||||||||:||||||.|:|||||||::......|.||:||.||||:|::.|.|:
Frog   825 KIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPSISEDESLQRLQKESEILQRTYAHY 889

  Fly   862 FDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
            |||||:||:|.|||..||.||:.|.|.||||||||:|
Frog   890 FDLTIINNEIDETIRHLEDAIELVCTAPQWVPVSWVY 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	203/300 (68%)
		S_TKc	12..278	CDD:214567	184/265 (69%)
		L27	347..396	CDD:280918	18/49 (37%)
		L27	406..462	CDD:280918	23/55 (42%)
		PDZ_signaling	493..573	CDD:238492	65/79 (82%)
		SH3_CASK	586..646	CDD:213014	40/60 (67%)
		Guanylate_kin	710..883	CDD:279019	124/172 (72%)
		GuKc	720..883	CDD:214504	115/162 (71%)
cask	XP_012812392.1	STKc_CASK	8..307	CDD:270996	203/300 (68%)
		L27	348..401	CDD:197794	18/53 (34%)
		L27	406..456	CDD:367207	23/55 (42%)
		PDZ_signaling	488..568	CDD:238492	65/79 (82%)
		SH3_MPP1-like	616..677	CDD:212968	40/60 (67%)
		Guanylate_kin	738..911	CDD:366206	124/172 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	382	1.000	Domainoid score	I825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2736
Inparanoid	1	1.050	1119	1.000	Inparanoid score	I229
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0006854
OrthoInspector	1	1.000	-	-		oto104229
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2610
SonicParanoid	1	1.000	-	-		X4946
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090