DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and camk2d2

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_009304932.1	Gene:	camk2d2 / 436815	ZFINID:	ZDB-GENE-040718-277	Length:	554	Species:	Danio rerio

Alignment Length:	307	Identity:	136/307 - (44%)
Similarity:	189/307 - (61%)	Gaps:	17/307 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69
            |.|.|:|.|.:|||.||:||||:...|.|::|.||::..|      ||..|   |:|||.||.:|
Zfish     9 FTDEYQLFEELGKGAFSVVRRCVKISSGQEYAAKIINTKK------LSARDHQKLEREARICRLL 67

  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134
            |||:||.|.::.|.||..|:||:.:.|.:|..::|.|.    .||||.|.|.::||||::.:||.
Zfish    68 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILESVHHCHV 128

  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199
            |.|:|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
Zfish   129 NGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQA--WFGFAGTPGYLSPEVLRKDPYG 191

  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
Zfish   192 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 256

  Fly   264 HHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAV 309
            ..|::..|.|.||||..|..: ...|..:|||.||::|||||||||:
Zfish   257 SKRITAAEALKHPWICQRSTVASMMHRQETVECLKKFNARRKLKGAI 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	134/304 (44%)
		S_TKc	12..278	CDD:214567	116/269 (43%)
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
camk2d2	XP_009304932.1	STKc_CaMKII	11..302	CDD:270988	133/302 (44%)
		S_TKc	13..271	CDD:214567	116/269 (43%)
		CaMKII_AD	422..549	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810