DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and MPP3

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001317162.1	Gene:	MPP3 / 4356	HGNCID:	7221	Length:	610	Species:	Homo sapiens

Alignment Length:	642	Identity:	194/642 - (30%)
Similarity:	329/642 - (51%)	Gaps:	108/642 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 AGGTNMDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDN 377
            :||.|        |.||:       ..|::|:.....:|  ...:....:...:...|||:..:.
Human    19 SGGDN--------ASMPV-------LSEDSGLHETLALL--TSQLRPDSNHKEEMGFLRDVFSEK 66

  Fly   378 ------RLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMR 436
                  ::|:.|:.::|.:.|.|..:       ||....||:|:|.:.|..:.      :.||::
Human    67 SLSYLMKIHEKLRYYERQSPTPVLHS-------AVALAEDVMEELQAASVHSD------ERELLQ 118

  Fly   437 LLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNV-EGGELQHVTRVRLVQFQK 500
            ||:.||::|:|..||.||:..:         .|::|.|.    ||: |..:.:.|..||||   |
Human   119 LLSTPHLRAVLMVHDTVAQKNF---------DPVLPPLP----DNIDEDFDEESVKIVRLV---K 167

  Fly   501 NTDEPMGITLKMTE-DGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREA 564
            | .||:|.|::..| .|..:|||||.||...|...:|||||:||:||..|.|:...::.::|.::
Human   168 N-KEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQS 231

  Fly   565 RGSVTFKIVPSYRSAP--PPCEIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWW 627
            :||:|.||:|:.:...  ...::|:||.|.|||.:|..|||.:||:.||...:|:::|:||..||
Human   232 QGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWW 296

  Fly   628 QARLDTVGGS---AGLIPSPELQEWRIAC----------QTVDKTKQEQ----VNCSIFGRKKKQ 675
            ||:  .||.:   ||||||...||.|::.          |::.|...:|    ..|...|..|..
Human   297 QAK--RVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGH 359

  Fly   676 ------------CRDK----YLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGR 724
                        ||::    ...|.::..::.:::|||||.:.. ..|..:.:.:||:|:.|...
Human   360 YVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQ-HQPGERPRLVVLIGSLGARL 423

  Fly   725 RHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYG 789
            ..:|..::::.|..:...:||||||.|..|:.|..|:|||.....||:..|::||:|.:::.:||
Human   424 HELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYG 488

  Fly   790 TKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQ--------------NIADY 840
            |.|:.|:.:..:.|:.::||||:|||.|||:||.||::|: .|::|              ..|.:
Human   489 TSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFV-KPAIQEKRKTPPMSPACEDTAAPF 552

  Fly   841 DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897
            |...:.:|..:..:.:.|||..|..:|..|:....:.|:..::::.....||||||:
Human   553 DEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWV 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	9/54 (17%)
		L27	406..462	CDD:280918	18/55 (33%)
		PDZ_signaling	493..573	CDD:238492	36/80 (45%)
		SH3_CASK	586..646	CDD:213014	31/62 (50%)
		Guanylate_kin	710..883	CDD:279019	58/186 (31%)
		GuKc	720..883	CDD:214504	55/176 (31%)
MPP3	NP_001317162.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810