DRSC/TRiP Functional Genomics Resources

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Protein Alignment CASK and MPP2

DIOPT Version :9

Sequence 1:NP_001262811.1 Gene:CASK / 42567 FlyBaseID:FBgn0013759 Length:929 Species:Drosophila melanogaster
Sequence 2:XP_011523129.2 Gene:MPP2 / 4355 HGNCID:7220 Length:630 Species:Homo sapiens


Alignment Length:692 Identity:252/692 - (36%)
Similarity:361/692 - (52%) Gaps:109/692 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 LVMKMLAANPHHRLSITEVLDHPWIRDRD-KLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTN 317
            :|....:|.|...:....||..|   .|| .|.:..|:|       .::....:...:|:|..| 
Human     1 MVQACTSAWPFDPILWPSVLSRP---PRDLSLSKAPLSD-------LSSPHLFERRFRALASFT- 54

  Fly   318 MDPLYATDADMPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAH----------VDADVLRD 372
                      ||:.....|        .|:|::||.|..:.|...|.          :::.::|.
Human    55 ----------MPVAATNSE--------TAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRS 101

  Fly   373 MLRDNRLHQFLQ---------------LFDRIAAT---VVTSNGRAPAAEAVGRCRDVLEQLSST 419
            :.:...:..|:|               ..:|:..|   .|..|......|.:.....:.|| |||
Human   102 LAKVIMVLWFMQQNVFVPMKYMLKYFGAHERLEETKLEAVRDNNLELVQEILRDLAQLAEQ-SST 165

  Fly   420 SGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEG 484
            :.           ||..:|..||.|:||.:||.||...|      .||||      ...||....
Human   166 AA-----------ELAHILQEPHFQSLLETHDSVASKTY------ETPPP------SPGLDPTFS 207

  Fly   485 GELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPV 549
            .:......||:|..:|...|.:|:|.:: |.|..::|||:||||:.:|..|||||.|:|:|||||
Human   208 NQPVPPDAVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV 271

  Fly   550 QHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQFDYNPLDDELIPCAQAGISFQVGD 614
             ......||.:||.|.|||..||:|||:....|.::||:..|||:|..|.||||.:||:.|..||
Human   272 -GSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGD 335

  Fly   615 ILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIAC--QTVDKTKQEQVNC-SIFGRKKKQC 676
            :|||:::||.:|||| ....|||||||||..|:|.|.|.  :.::.|......| |:.|:|||  
Human   336 LLQIVNQDDANWWQA-CHVEGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKK-- 397

  Fly   677 RDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAY 741
            |..||...||.||..:::.||||.::    |.|:||||||:||.|||||.:||.||...||:|..
Human   398 RMMYLTTKNAEFDRHELLIYEEVARM----PPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGT 458

  Fly   742 PIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAI 806
            .:|:|:|..|..|..|:.|.|||..||.||:.|..|||:|.:|..:|||::|:||.:...||:.:
Human   459 TVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCV 523

  Fly   807 LDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY---------------DGSLERLAKESEMLRQ 856
            |||.|||:|:||||||.||||||.||..:.:...               :..|.|..:||..:::
Human   524 LDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQR 588

  Fly   857 LYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
            .|||:|||.:||:::..|...|:||::::.|.||||||||:|
Human   589 GYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CASKNP_001262811.1 STKc_CASK 8..308 CDD:270996 11/54 (20%)
S_TKc 12..278 CDD:214567 6/23 (26%)
L27 347..396 CDD:280918 12/76 (16%)
L27 406..462 CDD:280918 18/55 (33%)
PDZ_signaling 493..573 CDD:238492 38/79 (48%)
SH3_CASK 586..646 CDD:213014 34/59 (58%)
Guanylate_kin 710..883 CDD:279019 85/187 (45%)
GuKc 720..883 CDD:214504 77/177 (44%)
MPP2XP_011523129.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D364535at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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