DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and mpp2b

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	XP_005156123.1	Gene:	mpp2b / 431770	ZFINID:	ZDB-GENE-040704-70	Length:	561	Species:	Danio rerio

Alignment Length:	585	Identity:	234/585 - (40%)
Similarity:	330/585 - (56%)	Gaps:	80/585 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 AVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEA----- 405
            |:|.:||.|.|..|...|: |.|::           ||:  ..:.:.|...:...|..||
Zfish    25 AMQSLLDTLSDSTSSTTAN-DLDLI-----------FLK--GIMESPVSREHYEEPKLEAVRDNN 75

  Fly   406 VGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPP- 469
            |...:|:|..|::.|..:.     |..||:.:|..||.|:||.:||.||...|      .||||
Zfish    76 VELVQDILRDLNTLSPDSP-----AAHELICILKEPHFQSLLETHDSVASKSY------ETPPPS 129

  Fly   470 ----MVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIH 530
                |.|..|...:.         ...||:|..:|.:.|.:|:|.:: |.|..::|||:|||||.
Zfish   130 PCAFMDPAFNNQPVP---------PDAVRMVGIRKVSGEHLGVTFRV-EGGELVIARILHGGMID 184

  Fly   531 RQATLHVGDEIREINGQPVQHQSVGQ----LQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQF 591
            :|..|||||.|:|:||     :.||.    ||.||:|:.|||..||:|||:....|.:.||:..|
Zfish   185 QQGLLHVGDIIKEVNG-----KEVGSDPKVLQNMLKESSGSVVLKILPSYQEPHTPRQAFVKCHF 244

  Fly   592 DYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQA-RLDTVGGSAGLIPSPELQEWRIAC-- 653
            ||:|..|.||||.:||:.|..||||||.:::|.:|||| .|:  |||||||||..|:|.|.|.
Zfish   245 DYDPSHDNLIPCKEAGLKFSSGDILQIFNQEDPNWWQACHLE--GGSAGLIPSQLLEEKRKAFVK 307

  Fly   654 QTVDKTKQEQVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLG 718
            :.::......:...|.|:|||:.  .||...||.||..::..||||.:|    |.|:||||||:|
Zfish   308 RDLELASTGPLCAGIGGKKKKKM--MYLTTKNAEFDRHELRIYEEVARV----PPFRRKTLVLIG 366

  Fly   719 AHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTH 783
            |.|||||.:||.|:...|.:|....|:|:|..|.:|:.|:.|.|:|..||..||....:||:|.:
Zfish   367 AQGVGRRSLKNKLLVSDPHRYGTTTPYTSRKPKVDEKEGQMYLFMSRSEMETDIKCGRFLEHGEY 431

  Fly   784 EDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADY-------- 840
            :..:||||:|:|..:...||:.||||.|||||:||||||.||||||.||:.:.:.|.
Zfish   432 DGNLYGTKIDSIHEVVDSGKICILDVNPQALKVLRTAEFLPYVVFIEAPNFEVLKDMNRSAIEAG 496

  Fly   841 -------DGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
                   |..|:|...|||.:::.|.|:|||:|||:::.....:|..|:||::|..|||||||::
Zfish   497 VVTKQMTDSELKRTVDESERIQRAYSHYFDLSIVNDNLDGAYRSLRRALDRLNTDQQWVPVSWVF 561

Fly 899 898
Zfish 562 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	12/48 (25%)
		L27	406..462	CDD:280918	19/55 (35%)
		PDZ_signaling	493..573	CDD:238492	38/83 (46%)
		SH3_CASK	586..646	CDD:213014	35/60 (58%)
		Guanylate_kin	710..883	CDD:279019	82/187 (44%)
		GuKc	720..883	CDD:214504	74/177 (42%)
mpp2b	XP_005156123.1	L27	76..127	CDD:280918	20/61 (33%)
		PDZ_signaling	148..226	CDD:238492	38/83 (46%)
		SH3_MPP2	239..297	CDD:212970	35/59 (59%)
		Guanylate_kin	358..546	CDD:279019	82/187 (44%)
		GuKc	368..546	CDD:214504	74/177 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820