DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CASK and pyd

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	897	Identity:	178/897 - (19%)
Similarity:	291/897 - (32%)	Gaps:	280/897 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 ETIETHGRVGCPHYMAPEVVTRRLYGKG-CDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRL 237
            ||..||..           ..||.:.|| ...|    ..|.:...|:|..|.|:    :|:.||
  Fly   225 ETASTHSS-----------SQRRRFKKGDRTTW----EYHTVAVTRVPGYGFGI----AVSGGR- 269

  Fly   238 SFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVL------DHPWIRDR------DKLQRTHLA 290
              :.|.:                ||....:::::||      |...:.||      ..|:....|
  Fly   270 --DNPHF----------------ANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYA 316

  Fly   291 DTVEELK------RYNARRKL-------KGAVQ-----------AIAGGT-NMDPLYATDADMP- 329
            ..|:.|:      :...:|::       .||||           .:|.|: .:.|...|....|
  Fly   317 TAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPN 381

  Fly   330 -----------------IT----GATDEW----------------ADEEAGI--------EAVQR 349
                             :|    |..|::                |.|:...        :.:.|
  Fly   382 SLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITR 446

  Fly   350 I--LDCLDDIYSLQDAHVDAD---------VLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAA 403
            |  .:| .|..||::|....|         ||||:.....:.| |.| :..|:...:.|..|...
  Fly   447 IHNTNC-GDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQ-LNL-NNSASHQASGNIYATHQ 508

  Fly   404 EAVGRCRDVLEQL---------------------SSTSGGNSLGGKYAKEELMRLL-----AAPH 442
            ..|..|......|                     :.||.|.::.|....:|...|.     ..|.
  Fly   509 PQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPI 573

  Fly   443 MQAL-LHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGG--------------ELQHVTR 492
            |..: |...|.......|..| .:..||..|...|.     .||              |.:....
  Fly   574 MDGVSLQQLDRPVTPTRGRSA-AIDEPPRPPPPRGS-----SGGAAQEDFYSSRRQLYEERQSAE 632

  Fly   493 VRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQL 557
            .|.:.|||  :..:||.|....:....|..:..|.....|. |..||:|.::|...:...:..:.
  Fly   633 PRFISFQK--EGSVGIRLTGGNEAGIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREEA 694

  Fly   558 QRMLREARGSVTF----------KIVPSYRSAPPPCEIFVRAQFDY-NPLDDELIPCAQAGISFQ 611
            ...|...:..:..          ::|.:.|..    ...::..|.. ||...|:        :|:
  Fly   695 VLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGD----SFHIKTHFHCDNPSKGEM--------AFK 747

  Fly   612 VGDILQIISKDDHH-----WWQARLDTVGG----SAGLIPSPELQEWRIACQTVDKTKQE----Q 663
            .||:.::|  |..|     .||. |....|    ..|:||:....| .:|....:.||:|    :
  Fly   748 AGDVFRVI--DTLHNGVVGSWQV-LKIGRGHQEMQRGVIPNKSRAE-ELATAQFNATKKEMNANE 808

  Fly   664 VNCSIFGRKKK-QCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGD------PNFQRKTLVLLGAHG 721
            ...:.|.|::. ..|.|.|::.|  :|  |||..:.:.|.|..:      |.|.|..::......
  Fly   809 SRGNFFRRRRSTHRRSKSLSREN--WD--DVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSD 869

  Fly   722 VGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDA 786
            :.|..    |...:|||::.|:.                   ..|:..|..|....:
  Fly   870 LARER----LAKDFPDKFSTPLQ-------------------DDDKSAATSGKCRIV-------- 903

  Fly   787 MYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSL------- 844
                :|..||.:...||.|:||:.|.|:..|..|:|.|.|:|:...|...|......|
  Fly   904 ----RLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKS 964

  Fly   845 -ERLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVS 895
             ::|.::.:.|.:::.|.|...|..:|.......|..:||...:...|:..|
  Fly   965 SKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSES 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	30/159 (19%)
		S_TKc	12..278	CDD:214567	23/110 (21%)
		L27	347..396	CDD:280918	16/59 (27%)
		L27	406..462	CDD:280918	14/82 (17%)
		PDZ_signaling	493..573	CDD:238492	16/89 (18%)
		SH3_CASK	586..646	CDD:213014	17/69 (25%)
		Guanylate_kin	710..883	CDD:279019	36/180 (20%)
		GuKc	720..883	CDD:214504	35/170 (21%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	20/107 (19%)
		PDZ_signaling	396..477	CDD:238492	13/81 (16%)
		PDZ_signaling	633..710	CDD:238492	16/79 (20%)
		SH3_ZO	729..790	CDD:212793	17/71 (24%)
		GuKc	831..1007	CDD:214504	47/214 (22%)
		ZU5	2263..2351	CDD:279170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910