DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASK and pals2a

DIOPT Version :9

Sequence 1:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster
Sequence 2:	NP_001243118.1	Gene:	pals2a / 402878	ZFINID:	ZDB-GENE-050506-35	Length:	550	Species:	Danio rerio

Alignment Length:	572	Identity:	225/572 - (39%)
Similarity:	328/572 - (57%)	Gaps:	51/572 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 AVQRILDCLDDIYSLQDA-HVDADVLRDMLRDNRLHQFLQLFDR---IAATVVTSNGRAPAAEAV 406
            |:|::||.|.::.....| .:|...||.::....:....:..:|   :....|.||.    .|.|
Zfish    11 AMQQVLDNLKELPPSTGAKDIDLIFLRGIMESPIVRSLAKAHERLEDVKLEAVQSNN----VELV 71

  Fly   407 GRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMV 471
            .   ::|..:||.     :....:..||..:|..||.|:||.:||.||...|  ||     ||
Zfish    72 S---EILSDMSSL-----IIRDESAAELSNILKEPHFQSLLEAHDKVASKSY--EA-----PP-- 119

  Fly   472 PYLNGDELDNVEGGELQHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLH 536
               ......::....|.....||::..||...||:|:|.:: |:|..::||::||.||.||..||
Zfish   120 ---TSTNSTSMSSSSLMPADTVRMISIQKKAGEPLGVTFRV-EEGDLVIARVLHGSMIDRQGMLH 180

  Fly   537 VGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEIFVRAQFDYNPLDDELI 601
            .||.|||:||:.|....:. ||.|||:..||:|.||:|||:..|||.:::::..|:|||..|.||
Zfish   181 AGDVIREVNGREVGKDPMA-LQHMLRDCNGSITLKILPSYKDTPPPAQVYLKPHFNYNPNTDNLI 244

  Fly   602 PCAQAGISFQVGDILQIISKDDHHWWQARLDTVGGSAGLIPSPELQEWRIACQTVDKTKQEQVNC 666
            ||.:||::|..||||.|::|:|.:|||| .:..||..|||||..|:|.|.|....| .....:.|
Zfish   245 PCREAGLAFSKGDILHIVNKEDPNWWQA-CNINGGHTGLIPSQFLEEKRKAFVRRD-LDGSGILC 307

  Fly   667 SIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTL 731
            .....|||:.:..||...||.||..::..||||.|:    |.||||||||:||.|||||.:||.|
Zfish   308 GTLTGKKKKKKMMYLTAKNAEFDRHELQIYEEVAKM----PPFQRKTLVLIGAQGVGRRSLKNRL 368

  Fly   732 ISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIR 796
            |...|.:|...:|.|:|..:.:|::|:||.|||.:||..||.|:.|||:|.::..:||||:|:|.
Zfish   369 IVLNPLRYGTTVPFTSRRPRDDEKDGQSYCFVSREEMEMDIKASRYLEHGEYDGNLYGTKMDSIH 433

  Fly   797 RIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNI-----ADYDG----------SLER 846
            .:...|:..||||.|||||:|:|:||.|:|||||||.|..:     |..|.          .|::
Zfish   434 EVVRAGRTCILDVNPQALKVLKTSEFMPFVVFIAAPELDTLRAMHKAVVDAGITTKLLTETDLKK 498

  Fly   847 LAKESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898
            ...||..:::.|.|:|||||||:::.:....|:.|::::.|.||||||:|:|
Zfish   499 TVDESARIKRAYNHYFDLTIVNDNLDKAFEKLQAAVEQLTTQPQWVPVNWVY 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	10/52 (19%)
		L27	406..462	CDD:280918	17/55 (31%)
		PDZ_signaling	493..573	CDD:238492	37/79 (47%)
		SH3_CASK	586..646	CDD:213014	30/59 (51%)
		Guanylate_kin	710..883	CDD:279019	84/187 (45%)
		GuKc	720..883	CDD:214504	75/177 (42%)
pals2a	NP_001243118.1	L27	13..66	CDD:197794	10/52 (19%)
		L27	68..119	CDD:308467	20/65 (31%)
		PDZ_signaling	138..216	CDD:238492	37/79 (47%)
		SH3_MPP	229..286	CDD:212796	29/57 (51%)
		Guanylate_kin	347..537	CDD:331880	84/189 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750